Evidence map›Paper›PMID 20686022›Full record

ArticleJournal of virology2010

Mononucleosis and antigen-driven T cell responses have different requirements for interleukin-2 signaling in murine gammaherpesvirus infection.

Michael Molloy, Weijun Zhang, Edward Usherwood

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Michael MolloyDartmouth Medical School, Department of Microbiology & Immunology, 1 Medical Center Drive, Lebanon, NH 03756, USA.
Weijun Zhang
Edward Usherwood

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Steven D Leach · 1985 to 2026
$91.3M
IMMUNOBIOLOGY OF MYELOID AND LYMPHOID CELLST32AI007363 · NIAID · DARTMOUTH COLLEGE · PI Claudia V Jakubzick · 1990 to 2026
$9.5M
T cell function in murine gammaherpesvirus infectionR01AI069943 · NIAID · DARTMOUTH COLLEGE · PI USHERWOOD, EDWARD J · 2007 to 2016
$3.3M
Immune surveillance in murine gammaherpesvirus infectionR01CA103642 · NCI · DARTMOUTH COLLEGE · PI USHERWOOD, EDWARD J · 2004 to 2013
$3.1M
T cell function in murine gammaherpesvirus infectionR56AI069943 · NIAID · DARTMOUTH COLLEGE · PI USHERWOOD, EDWARD J · 2012 to 2012
$403k
NCI NIH HHS CA103642NCI NIH HHS P30 CA023108NCI NIH HHS R01 CA103642NIAID NIH HHS AI069943NIAID NIH HHS R01 AI069943NIAID NIH HHS R56 AI069943NIAID NIH HHS T32 AI007363NIAID NIH HHS T32AI07363
6 · The paper itself

Abstract

Interleukin-2 (IL-2) has been implicated as being necessary for the optimal formation of primary CD8(+) T cell responses against various pathogens. Here we have examined the role that IL-2 signaling plays in several aspects of a CD8(+) T cell response against murine gammaherpesvirus 68 (MHV-68). Exposure to MHV-68 causes a persistent infection, along with infectious mononucleosis, providing a model for studying these processes in mice. Our study indicates that CD25 is necessary for optimal expansion of the antigen-specific CD8(+) T cell response but not for the long-term memory response. Contrastingly, IL-2 signaling through CD25 is absolutely required for CD8(+) T cell mononucleosis.

Indexed as

RhadinovirusAnimalsAntigens, ViralCD8-Positive T-LymphocytesDisease Models, AnimalHerpesviridae InfectionsHumansInfectious MononucleosisInterleukin-2Interleukin-2 Receptor alpha SubunitMiceMice, CongenicMice, Inbred C57BLMice, KnockoutSignal TransductionTumor Virus InfectionsAntigens, ViralIl2ra protein, mouseInterleukin-2Interleukin-2 Receptor alpha Subunit

Identifiers

PMID20686022
PMCPMC2950560
OpenAlexW2024079052

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.