ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
In vivo activation of channelrhodopsin-2 reveals that normal patterns of spontaneous activity are required for motoneuron guidance and maintenance of guidance molecules.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Chloride Modulates Central pH Sensitivity and Plasticity of Brainstem Breathing-Related Biorhythms in Zebra Finch Embryos.Developmental psychobiology · 2024Article
- Optogenetic control of gut movements reveals peristaltic wave-mediated induction of cloacal contractions and reactivation of impaired gut motility.Frontiers in physiology · 2023Article
- Epigenetic and Transcriptional Regulation of Spontaneous and Sensory Activity Dependent Programs During Neuronal Circuit Development.Frontiers in neural circuits · 2022Review
- Prenatal exposure to nicotine disrupts synaptic network formation by inhibiting spontaneous correlated wave activity.IBRO reports · 2020Article
- Driving Neurogenesis in Neural Stem Cells with High Sensitivity Optogenetics.Neuromolecular medicine · 2020Article
- Stem cell transplantation therapy for multifaceted therapeutic benefits after stroke.Progress in neurobiology · 2017Review
- Article
- Normal Molecular Specification and Neurodegenerative Disease-Like Death of Spinal Neurons Lacking the SNARE-Associated Synaptic Protein Munc18-1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Spontaneous Neuronal Activity in Developing Neocortical Networks: From Single Cells to Large-Scale Interactions.Frontiers in neural circuits · 2016Review
- Connectivity of pacemaker neurons in the neonatal rat superficial dorsal horn.The Journal of comparative neurology · 2015Article
- A spinal opsin controls early neural activity and drives a behavioral light response.Current biology : CB · 2015Article
- Can simple rules control development of a pioneer vertebrate neuronal network generating behavior?The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Emergence of motor circuit activity.PloS one · 2014Article
- Review
- Uncoupling of EphA/ephrinA signaling and spontaneous activity in neural circuit wiring.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Optogenetic-mediated increases in in vivo spontaneous activity disrupt pool-specific but not dorsal-ventral motoneuron pathfinding.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Large-scale synchronized activity in the embryonic brainstem and spinal cord.Frontiers in cellular neuroscience · 2013Article
- Electrical activity as a developmental regulator in the formation of spinal cord circuits.Current opinion in neurobiology · 2012Review
- Neurotransmitter phenotype plasticity: an unexpected mechanism in the toolbox of network activity homeostasis.Developmental neurobiology · 2012Review
- Visual map development depends on the temporal pattern of binocular activity in mice.Nature neuroscience · 2011Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Spontaneous, highly rhythmic episodes of propagating bursting activity are present early during the development of chick and mouse spinal cords. Acetylcholine, and GABA and glycine, which are both excitatory at this stage, provide the excitatory drive. It was previously shown that a moderate decrease in the frequency of bursting activity, caused by in ovo application of the GABA(A) receptor blocker, picrotoxin, resulted in motoneurons making dorsal-ventral (D-V) pathfinding errors in the limb and in the altered expression of guidance molecules associated with this decision. To distinguish whether the pathfinding errors were caused by perturbation of the normal frequency of bursting activity or interference with GABA(A) receptor signaling, chick embryos were chronically treated in ovo with picrotoxin to block GABA(A) receptors, while light activation by channelrhodopsin-2 was used to restore bursting activity to the control frequency. The restoration of normal patterns of neural activity in the presence of picrotoxin prevented the D-V pathfinding errors in the limb and maintained the normal expression levels of EphA4, EphB1, and polysialic acid on neural cell adhesion molecule, three molecules previously shown to be necessary for this pathfinding choice. These observations demonstrate that developing spinal motor circuits are highly sensitive to the precise frequency and pattern of spontaneous activity, and that any drugs that alter this activity could result in developmental defects.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.