ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
A novel transient glutamatergic population migrating from the pallial-subpallial boundary contributes to neocortical development.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 77 citations in OpenAlex.
- Nurr1 Orchestrates Claustrum Development and Functionality.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Neurotrophin-3 produced by motor neurons non-cell autonomously regulate the development of pre-motor interneurons in the developing spinal cord.bioRxiv : the preprint server for biology · 2026Article
- Construction of a molecular diagnostic system for neurogenic rosacea by combining transcriptome sequencing and machine learning.BMC medical genomics · 2024Article
- Specific contribution of neurons from the Dbx1 lineage to the piriform cortex.Scientific reports · 2021Article
- Sim1-expressing cells illuminate the origin and course of migration of the nucleus of the lateral olfactory tract in the mouse amygdala.Brain structure & function · 2021Article
- Development of the mouse anterior amygdalar radial unit marked by Lhx9-expression.Brain structure & function · 2021Article
- Variations of telencephalic development that paved the way for neocortical evolution.Progress in neurobiology · 2020Review
- Developmental cell death regulates lineage-related interneuron-oligodendroglia functional clusters and oligodendrocyte homeostasis.Nature communications · 2019Article
- Cell migration promotes dynamic cellular interactions to control cerebral cortex morphogenesis.Nature reviews. Neuroscience · 2019Review
- Conserved and divergent functions of Pax6 underlie species-specific neurogenic patterns in the developing amniote brain.Development (Cambridge, England) · 2018Article
- Absence of Tangentially Migrating Glutamatergic Neurons in the Developing Avian Brain.Cell reports · 2018Article
- Dbx1-Derived Pyramidal Neurons Are Generated Locally in the Developing Murine Neocortex.Frontiers in neuroscience · 2018Article
- Lateral Thalamic Eminence: A Novel Origin for mGluR1/Lot Cells.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Rostro-Caudal and Caudo-Rostral Migrations in the Telencephalon: Going Forward or Backward?Frontiers in neuroscience · 2017Review
- Evidence That the Laminar Fate of LGE/CGE-Derived Neocortical Interneurons Is Dependent on Their Progenitor Domains.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Tangential migration of neuronal precursors of glutamatergic neurons in the adult mammalian brain.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Molecular Pathways Underlying Projection Neuron Production and Migration during Cerebral Cortical Development.Frontiers in neuroscience · 2015Review
- Control of cortical neuronal migration by glutamate and GABA.Frontiers in cellular neuroscience · 2015Review
- A hypothesis for the evolution of the upper layers of the neocortex through co-option of the olfactory cortex developmental program.Frontiers in neuroscience · 2015Article
- Switching modes in corticogenesis: mechanisms of neuronal subtype transitions and integration in the cerebral cortex.Frontiers in neuroscience · 2015Review
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The generation of a precise number of neural cells and the determination of their laminar fate are tightly controlled processes during development of the cerebral cortex. Using genetic tracing in mice, we have identified a population of glutamatergic neurons generated by Dbx1-expressing progenitors at the pallial-subpallial boundary predominantly at embryonic day 12.5 (E12.5) and subsequent to Cajal-Retzius cells. We show that these neurons migrate tangentially to populate the cortical plate (CP) at all rostrocaudal and mediolateral levels by E14.5. At birth, they homogeneously populate cortical areas and represent <5% of cortical cells. However, they are distributed into neocortical layers according to their birthdates and express the corresponding markers of glutamatergic differentiation (Tbr1, ER81, Cux2, Ctip2). Notably, this population dies massively by apoptosis at the completion of corticogenesis and represents 50% of dying neurons in the postnatal day 0 cortex. Specific genetic ablation of these transient Dbx1-derived CP neurons leads to a 20% decrease in neocortical cell numbers in perinatal animals. Our results show that a previously unidentified transient population of glutamatergic neurons migrates from extraneocortical regions over long distance from their generation site and participates in neocortical radial growth in a non-cell-autonomous manner.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.