ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
LIM-homeobox gene Lhx5 is required for normal development of Cajal-Retzius cells.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 56 citations in OpenAlex.
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- Cell-type-specific dysregulation of gene expression due to Chd8 haploinsufficiency during mouse cortical development.Cell genomics · 2025Article
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- Early Life Events and Maturation of the Dentate Gyrus: Implications for Neurons and Glial Cells.International journal of molecular sciences · 2022Review
- Involvement of Mechanical Cues in the Migration of Cajal-Retzius Cells in the Marginal Zone During Neocortical Development.Frontiers in cell and developmental biology · 2022Article
- Genetic Regulation of Vertebrate Forebrain Development by Homeobox Genes.Frontiers in neuroscience · 2022Review
- Quail-chick grafting experiments corroborate that Tbr1-positive eminential prethalamic neurons migrate along three streams into hypothalamus, subpallium and septocommissural areas.Brain structure & function · 2021Article
- Single-cell atlas of early human brain development highlights heterogeneity of human neuroepithelial cells and early radial glia.Nature neuroscience · 2021Article
- Integrative genomic analysis of early neurogenesis reveals a temporal genetic program for differentiation and specification of preplate and Cajal-Retzius neurons.PLoS genetics · 2021Article
- The Role of ISL1 and LHX5 LIM Homeobox Genes in Bladder Tumourigenesis.The Malaysian journal of medical sciences : MJMS · 2020Article
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- Ex Vivo Oculomotor Slice Culture from Embryonic GFP-Expressing Mice for Time-Lapse Imaging of Oculomotor Nerve Outgrowth.Journal of visualized experiments : JoVE · 2019Article
- Overexpression of NEUROG2 and NEUROG1 in human embryonic stem cells produces a network of excitatory and inhibitory neurons.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Inferring Novel Tumor Suppressor Genes with a Protein-Protein Interaction Network and Network Diffusion Algorithms.Molecular therapy. Methods & clinical development · 2018Article
- Neurophilic Descending Migration of Dorsal Midbrain Neurons Into the Hindbrain.Frontiers in neuroanatomy · 2018Article
- Lateral Thalamic Eminence: A Novel Origin for mGluR1/Lot Cells.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Origin and Migration of Olfactory Cajal-Retzius Cells.Frontiers in neuroanatomy · 2017Article
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Authors and funding
12 authors at 8 institutions in 3 countries.
Funding
Abstract
Cajal-Retzius (C-R) cells play important roles in the lamination of the mammalian cortex via reelin secretion. The genetic mechanisms underlying the development of these neurons have just begun to be unraveled. Here, we show that two closely related LIM-homeobox genes Lhx1 and Lhx5 are expressed in reelin+ cells in various regions in the mouse telencephalon at or adjacent to sites where the C-R cells are generated, including the cortical hem, the mantle region of the septal/retrobulbar area, and the ventral pallium. Whereas Lhx5 is expressed in all of these reelin-expressing domains, Lhx1 is preferentially expressed in the septal area and in a continuous domain spanning from lateral olfactory region to caudomedial territories. Genetic ablation of Lhx5 results in decreased reelin+ and p73+ cells in the neocortical anlage, in the cortical hem, and in the septal, olfactory, and caudomedial telencephalic regions. The overall reduction in number of C-R cells in Lhx5 mutants is accompanied by formation of ectopic reelin+ cell clusters at the caudal telencephalon. Based on differential expression of molecular markers and by fluorescent cell tracing in cultured embryos, we located the origin of reelin+ ectopic cell clusters at the caudomedial telencephalic region. We also confirmed the existence of a normal migration stream of reelin+ cells from the caudomedial area to telencephalic olfactory territories in wild-type embryos. These results reveal a complex role for Lhx5 in regulating the development and normal distribution of C-R cells in the developing forebrain.
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