ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Stress-evoked tyrosine phosphorylation of signal regulatory protein α regulates behavioral immobility in the forced swim test.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Mendelian Randomization Estimates the Effects of Plasma and Cerebrospinal Fluid Proteins on Intelligence, Fluid Intelligence Score, and Cognitive Performance.Molecular neurobiology · 2025Article
- Compound identification of Shuangxinfang and its potential mechanisms in the treatment of myocardial infarction with depression: insights from LC-MS/MS and bioinformatic prediction.Frontiers in pharmacology · 2025Article
- Gut microbiota regulate stress resistance by influencing microglia-neuron interactions in the hippocampus.Brain, behavior, & immunity - health · 2024Article
- Prior exposure to stress exacerbates neuroinflammation and causes long-term behavior changes in sepsis.Heliyon · 2023Article
- Roles of non-receptor tyrosine kinases in pathogenesis and treatment of depression.Journal of integrative neuroscience · 2022Review
- CD47 in the Brain and Neurodegeneration: An Update on the Role in Neuroinflammatory Pathways.Molecules (Basel, Switzerland) · 2021Review
- Linking protein to phenotype with Mendelian Randomization detects 38 proteins with causal roles in human diseases and traits.PLoS genetics · 2020Article
- Article
- Tyrosine phosphorylation of the transmembrane protein SIRPα: Sensing synaptic activity and regulating ectodomain cleavage for synapse maturation.The Journal of biological chemistry · 2018Article
- CD47-signal regulatory protein α signaling system and its application to cancer immunotherapy.Cancer science · 2018Review
- Nicotine-induced neuroplasticity counteracts the effect of schizophrenia-linked neuregulin 1 signaling on NMDAR function in the rat hippocampus.Neuropharmacology · 2017Article
- Article
- Reply to Altered Monoaminergic Systems and Depressive-like Behavior in Congenic Prion Protein Knock-out Mice.The Journal of biological chemistry · 2015Article
- Altered Monoaminergic Systems and Depressive-like Behavior in Congenic Prion Protein Knock-out Mice.The Journal of biological chemistry · 2015Article
- Protein tyrosine phosphatase SAP-1 protects against colitis through regulation of CEACAM20 in the intestinal epithelium.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Shp2 in forebrain neurons regulates synaptic plasticity, locomotion, and memory formation in mice.Molecular and cellular biology · 2015Article
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- Article
- SIRPα polymorphisms, but not the prion protein, control phagocytosis of apoptotic cells.The Journal of experimental medicine · 2013Article
- Synapse maturation by activity-dependent ectodomain shedding of SIRPα.Nature neuroscience · 2013Article
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17 authors.
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Abstract
Severe stress induces changes in neuronal function that are implicated in stress-related disorders such as depression. The molecular mechanisms underlying the response of the brain to stress remain primarily unknown, however. Signal regulatory protein alpha (SIRPalpha) is an Ig-superfamily protein that undergoes tyrosine phosphorylation and binds the protein tyrosine phosphatase Shp2. Here we show that mice expressing a form of SIRPalpha that lacks most of the cytoplasmic region manifest prolonged immobility (depression-like behavior) in the forced swim (FS) test. FS stress induced marked tyrosine phosphorylation of SIRPalpha in the brain of wild-type mice through activation of Src family kinases. The SIRPalpha ligand CD47 was important for such SIRPalpha phosphorylation, and CD47-deficient mice also manifested prolonged immobility in the FS test. Moreover, FS stress-induced tyrosine phosphorylation of both the NR2B subunit of the NMDA subtype of glutamate receptor and the K+-channel subunit Kvbeta2 was regulated by SIRPalpha. Thus, tyrosine phosphorylation of SIRPalpha is important for regulation of depression-like behavior in the response of the brain to stress.
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