ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Centrosome motility is essential for initial axon formation in the neocortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
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Who cites it
74 citing papers in PubMed.
- Centrosome migration and apical membrane formation during epithelial polarization in MDCK cysts.eLife · 2026Article
- GRASPs link Reelin to the Golgi during neocortical development to control neuronal migration and dendritogenesis.Communications biology · 2025Article
- Navigating centriolar satellites: the role of PCM1 in cellular and organismal processes.The FEBS journal · 2025Review
- Phase separation of microtubule-binding proteins - implications for neuronal function and disease.Journal of cell science · 2024Review
- Lateral expansion of the mammalian cerebral cortex is related to anchorage of centrosomes in apical neural progenitors.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- A role for the centrosome in regulating the rate of neuronal efferocytosis by microglia in vivo.eLife · 2022Article
- Microtubules are not required to generate a nascent axon in embryonic spinal neurons in vivo.EMBO reports · 2022Article
- TAOK2 rescues autism-linked developmental deficits in a 16p11.2 microdeletion mouse model.Molecular psychiatry · 2022Article
- Centrosome-dependent microtubule modifications set the conditions for axon formation.Cell reports · 2022Article
- Establishing neuronal polarity: microtubule regulation during neurite initiation.Oxford open neuroscience · 2022Review
- Centrosome, the Newly Identified Passenger through Tunneling Nanotubes, Increases Binucleation and Proliferation Marker in Receiving Cells.International journal of molecular sciences · 2021Article
- Centrosome-mediated microtubule remodeling during axon formation in human iPSC-derived neurons.The EMBO journal · 2021Article
- Optical manipulation of molecular function by chromophore-assisted light inactivation.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2021Review
- Maf1 regulates dendritic morphogenesis and influences learning and memory.Cell death & disease · 2020Article
- Pattern Formation and Complexity in Single Cells.Current biology : CB · 2020Review
- Effector gene expression underlying neuron subtype-specific traits in the Motor Ganglion of Ciona.Developmental biology · 2020Article
- Regulation of Neurogenesis by FGF Signaling and Neurogenin in the Invertebrate ChordateFrontiers in cell and developmental biology · 2020Article
- Radial somatic F-actin organization affects growth cone dynamics during early neuronal development.EMBO reports · 2019Article
- SIAH1 ubiquitin ligase mediates ubiquitination and degradation of Akt3 in neural development.The Journal of biological chemistry · 2019Article
- Isozyme-Specific Role of SAD-A in Neuronal Migration During Development of Cerebral Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
14 more citing papers are in PubMed but not listed here.
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The mechanisms underlying the normal development of neuronal morphology remain a fundamental question in neurobiology. Studies in cultured neurons have suggested that the position of the centrosome and the Golgi may predict the site of axon outgrowth. During neuronal migration in the developing cortex, however, the centrosome and Golgi are oriented toward the cortical plate at a time when axons grow toward the ventricular zone. In the current work, we use in situ live imaging to demonstrate that the centrosome and the accompanying polarized cytoplasm exhibit apical translocation in newborn cortical neurons preceding initial axon outgrowth. Disruption of centrosomal activity or downregulation of the centriolar satellite protein PCM-1 affects axon formation. We further show that downregulation of the centrosomal protein Cep120 impairs microtubule organization, resulting in increased centrosome motility. Decreased centrosome motility resulting from microtubule stabilization causes an aberrant centrosomal localization, leading to misplaced axonal outgrowth. Our results reveal the dynamic nature of the centrosome in developing cortical neurons, and implicate centrosome translocation and microtubule organization during the multipolar stage as important determinants of axon formation.
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