ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Long and short multifunicular projections of sacral neurons are activated by sensory input to produce locomotor activity in the absence of supraspinal control.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 61 citations in OpenAlex.
- Article
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- A Focal Traumatic Injury to the Neonatal Rodent Spinal Cord Causes an Immediate and Massive Spreading Depolarization Sustained by Chloride Ions, with Transient Network Dysfunction.Cellular and molecular neurobiology · 2025Article
- Improvement in Motor and Walking Capacity during Multisegmental Transcutaneous Spinal Stimulation in Individuals with Incomplete Spinal Cord Injury.International journal of molecular sciences · 2024Article
- Suprapontine Structures Modulate Brainstem and Spinal Networks.Cellular and molecular neurobiology · 2023Article
- Electrical epidural stimulation of the cervical spinal cord: implications for spinal respiratory neuroplasticity after spinal cord injury.Journal of neurophysiology · 2021Review
- Contralateral Axon Sprouting but Not Ipsilateral Regeneration Is Responsible for Spontaneous Locomotor Recovery Post Spinal Cord Hemisection.Frontiers in cellular neuroscience · 2021Article
- Direct evidence for decreased presynaptic inhibition evoked by PBSt group I muscle afferents after chronic SCI and recovery with step-training in rats.The Journal of physiology · 2020Article
- Delayed Injection of a Physically Cross-Linked PNIPAAm-ACS omega · 2020Article
- Propriospinal Neurons of L3-L4 Segments Involved in Control of the Rat External Urethral Sphincter.Neuroscience · 2020Article
- Rostral lumbar segments are the key controllers of hindlimb locomotor rhythmicity in the adult spinal rat.Journal of neurophysiology · 2019Article
- Brainstem Steering of Locomotor Activity in the Newborn Rat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- And yet it moves: Recovery of volitional control after spinal cord injury.Progress in neurobiology · 2018Review
- Repeated Bout Rate Enhancement Is Elicited by Various Forms of Finger Tapping.Frontiers in neuroscience · 2018Article
- Shaping the Output of Lumbar Flexor Motoneurons by Sacral Neuronal Networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Correction: Multi-site spinal stimulation strategies to enhance locomotion after paralysis.Neural regeneration research · 2017Article
- Article
- Multi-site spinal stimulation strategies to enhance locomotion after paralysis.Neural regeneration research · 2016Article
- Unique Spatiotemporal Neuromodulation of the Lumbosacral Circuitry Shapes Locomotor Success after Spinal Cord Injury.Journal of neurotrauma · 2016Article
- Inducing hindlimb locomotor recovery in adult rat after complete thoracic spinal cord section using repeated treadmill training with perineal stimulation only.Journal of neurophysiology · 2015Article
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Afferent input from load and joint receptors has been shown to reactivate the central pattern generators for locomotion (CPGs) in spinal cord injury patients and thereby improve their motor function and mobility. Elucidation of the pathways interposed between the afferents and CPGs is critical for the determination of the capacity of sensory input to activate the CPGs when the continuity of the white matter tracts is impaired following spinal cord injury. Using electrophysiological recordings, confocal imaging studies of spinal neurons and surgical manipulations of the white matter, we show that the capacity of sacrocaudal afferent (SCA) input to produce locomotor activity in isolated rat spinal cords depends not only on long ascending pathways, but also on recruitment of sacral proprioneurons interposed between the second order neurons and the hindlimb CPGs. We argue that large heterogeneous populations of second-order and proprioneurons whose crossed and uncrossed axons project rostrally through the ventral, ventrolateral/lateral and dorsolateral white matter funiculi contribute to the generation of the rhythm by the stimulated sacrocaudal input. The complex organization and multiple projection patterns of these populations enable the sacrocaudal afferent input to activate the CPGs even if the white matter pathways are severely damaged. Further studies are required to clarify the mechanisms involved in SCA-induced locomotor activity and assess its potential use for the rescue of lost motor functions after spinal cord injury.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.