ArticleMolecular biology of the cell2010
Vestigial is required during late-stage muscle differentiation in Drosophila melanogaster embryos.
Article in Molecular biology of the cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- A systematic review on the effects of acrylamide and bisphenol A on the development of Drosophila melanogaster.Molecular biology reports · 2022Pooled it
- Vestigial-like 4 Regulates Neurogenesis and Neural Crest Formation DuringJournal of developmental biology · 2026Article
- Genes regulating development and behavior exhibited altered expression in Drosophila melanogaster exposed to bisphenol A: use of real-time quantitative PCR (qRT-PCR) and droplet digital PCR (ddPCR) in genotoxicity study.Environmental science and pollution research international · 2021Article
- Anti-Fibrotic Activity of an Antimicrobial Peptide in a Drosophila Model.Journal of innate immunity · 2021Article
- Article
- Review
- The matrix protein Tiggrin regulates plasmatocyte maturation inDevelopment (Cambridge, England) · 2017Article
- From vestigial to vestigial-like: the Drosophila gene that has taken wing.Development genes and evolution · 2016Review
- Wnt-mediated repression via bipartite DNA recognition by TCF in the Drosophila hematopoietic system.PLoS genetics · 2014Article
- Insights into insect wing origin provided by functional analysis of vestigial in the red flour beetle, Tribolium castaneum.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Drosophila araucan and caupolican integrate intrinsic and signalling inputs for the acquisition by muscle progenitors of the lateral transverse fate.PLoS genetics · 2011Article
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3 authors at 1 institution in 1 country.
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Abstract
The somatic muscles of Drosophila develop in a complex pattern that is repeated in each embryonic hemi-segment. During early development, progenitor cells fuse to form a syncytial muscle, which further differentiates via expression of muscle-specific factors that induce specific responses to external signals to regulate late-stage processes such as migration and attachment. Initial communication between somatic muscles and the epidermal tendon cells is critical for both of these processes. However, later establishment of attachments between longitudinal muscles at the segmental borders is largely independent of the muscle-epidermal attachment signals, and relatively little is known about how this event is regulated. Using a combination of null mutations and a truncated version of Sd that binds Vg but not DNA, we show that Vestigial (Vg) is required in ventral longitudinal muscles to induce formation of stable intermuscular attachments. In several muscles, this activity may be independent of Sd. Furthermore, the cell-specific differentiation events induced by Vg in two cells fated to form attachments are coordinated by Drosophila epidermal growth factor signaling. Thus, Vg is a key factor to induce specific changes in ventral longitudinal muscles 1-4 identity and is required for these cells to be competent to form stable intermuscular attachments with each other.
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