Evidence map›Paper›PMID 20685935›Full record

ArticleClinical and vaccine immunology : CVI2010

Influence of advanced age on Mycobacterium bovis BCG vaccination in guinea pigs aerogenically infected with Mycobacterium tuberculosis.

Shihoko Komine-Aizawa, Toshio Yamazaki, Tsuyoshi Yamazaki, Shin-Ichiro Hattori, Yuji Miyamoto, Naoki Yamamoto, Shinji Haga, Masahiko Sugitani, Mitsuo Honda, Satoshi Hayakawa and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and vaccine immunology : CVI, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Tuberculosis in an Aging World.Pathogens (Basel, Switzerland) · 2022
    Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shihoko Komine-AizawaDivision of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, 30-1 Oyaguchi-Kamicho, Itabash-ku, Tokyo, Japan. ashiho@med.nihon-u.ac.jp
Toshio Yamazaki
Tsuyoshi Yamazaki
Shin-Ichiro Hattori
Yuji Miyamoto
Naoki Yamamoto
Shinji Haga
Masahiko Sugitani
Mitsuo Honda
Satoshi Hayakawa
Saburo Yamamoto

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mycobacterium bovis bacillus Calmette-Guérin (BCG) is the only tuberculosis (TB) vaccine currently available, but its efficacy against adult pulmonary TB remains controversial. BCG induces specific immune responses to mycobacterial antigens and may elicit protective immunity against TB. TB remains a major public health problem, especially among the elderly, yet the efficacy of BCG in the elderly is unknown. We investigated the ability of BCG vaccination to prevent TB in young (6-week-old), middle-aged (18-month-old), and old (60-month-old) guinea pigs. BCG-Tokyo vaccination reduced the growth of Mycobacterium tuberculosis H37Rv in all three groups. By use of an enzyme-linked immunospot (ELISPOT) assay, antigen-specific gamma interferon (IFN-γ)-producing cells were detected in the 60-month-old guinea pigs after a booster vaccination with BCG-Tokyo. Our findings suggest that BCG-Tokyo has a protective effect against tuberculosis infection regardless of age.

Indexed as

Age FactorsAnimalsFemaleGuinea PigsImmunization, SecondaryInterferon-gammaLymphocytesMycobacterium bovisMycobacterium tuberculosisTuberculosisTuberculosis VaccinesVaccinationInterferon-gammaTuberculosis Vaccines

Identifiers

PMID20685935
PMCPMC2953003

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.