ArticleDevelopment (Cambridge, England)2010
In vivo evidence for transdifferentiation of peripheral neurons.
Article in Development (Cambridge, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 24 citations in OpenAlex.
- The Gut-Brain-Microbiome Axis and Its Link to Autism: Emerging Insights and the Potential of Zebrafish Models.Frontiers in cell and developmental biology · 2021Review
- RING1B contributes to Ewing sarcoma development by repressing the NaV1.6 sodium channel and the NF-κB pathway, independently of the fusion oncoprotein.Oncotarget · 2016Article
- Spinal neurons require Islet1 for subtype-specific differentiation of electrical excitability.Neural development · 2014Article
- Modulation of dorsal root ganglion development by ErbB signaling and the scaffold protein Sorbs3.Development (Cambridge, England) · 2013Article
- Lineage specification in the fly nervous system and evolutionary implications.Cell cycle (Georgetown, Tex.) · 2013Review
- Article
- Time-lapse imaging of neural development: zebrafish lead the way into the fourth dimension.Genesis (New York, N.Y. : 2000) · 2011Review
- Brain-derived neurotrophic factor mediates non-cell-autonomous regulation of sensory neuron position and identity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
It is commonly thought that differentiated neurons do not give rise to new cells, severely limiting the potential for regeneration and repair of the mature nervous system. However, we have identified cells in zebrafish larvae that first differentiate into dorsal root ganglia sensory neurons but later acquire a sympathetic neuron phenotype. These transdifferentiating neurons are present in wild-type zebrafish. However, they are increased in number in larvae that have a mutant voltage-gated sodium channel gene, scn8aa. Sodium channel knock-down promotes migration of differentiated sensory neurons away from the ganglia. Once in a new environment, sensory neurons transdifferentiate regardless of sodium channel expression. These findings reveal an unsuspected plasticity in differentiated neurons that points to new strategies for treatment of nervous system disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.