ArticleThe Journal of biological chemistry2010
Interferon-gamma-mediated inhibition of serum response factor-dependent smooth muscle-specific gene expression.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Actin cytoskeletal dynamics in hepatic myofibroblasts and fibrosis.Nature reviews. Gastroenterology & hepatology · 2026Review
- Paxillin regulates liver fibrosis via actin polymerization and ERK activation in hepatic stellate cells.Journal of cell science · 2023Article
- Characterization of focal adhesion proteins in rodent hepatic stellate cells.Histochemistry and cell biology · 2022Article
- Mechanisms of liver injury in high fat sugar diet fed mice that lack hepatocyte X-box binding protein 1.PloS one · 2022Article
- Fibroblast-specific Stat1 deletion enhances the myofibroblast phenotype during tissue repair.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society · 2020Article
- Myocardin and myocardin-related transcription factor-A synergistically mediate actin cytoskeletal-dependent inhibition of liver fibrogenesis.American journal of physiology. Gastrointestinal and liver physiology · 2020Article
- Smooth Muscle α-Actin Deficiency Leads to Decreased Liver Fibrosis via Impaired Cytoskeletal Signaling in Hepatic Stellate Cells.The American journal of pathology · 2019Article
- Upregulation of the actin cytoskeleton via myocardin leads to increased expression of type 1 collagen.Laboratory investigation; a journal of technical methods and pathology · 2017Article
- The Molecular Basis of Portal Hypertension.Transactions of the American Clinical and Climatological Association · 2017Review
- Interferon-γ blocks signalling through PDGFRβ in human brain pericytes.Journal of neuroinflammation · 2016Article
- Caveolin-1 is upregulated in hepatic stellate cells but not sinusoidal endothelial cells after liver injury.Tissue & cell · 2016Article
- The mitochondria-targeted antioxidant MitoQ attenuates liver fibrosis in mice.International journal of physiology, pathophysiology and pharmacology · 2016Article
- Celiac Disease Histopathology Recapitulates Hedgehog Downregulation, Consistent with Wound Healing Processes Activation.PloS one · 2015Article
- RNase L attenuates mitogen-stimulated gene expression via transcriptional and post-transcriptional mechanisms to limit the proliferative response.The Journal of biological chemistry · 2014Article
- Vascular pathobiology in chronic liver disease and cirrhosis - current status and future directions.Journal of hepatology · 2014Review
- Cellular and molecular mechanisms in the pathogenesis of liver fibrosis: An update.World journal of gastroenterology · 2014Review
- Preproendothelin-1 expression is negatively regulated by IFNγ during hepatic stellate cell activation.American journal of physiology. Gastrointestinal and liver physiology · 2012Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
IFNγ exerts multiple biological effects on effector cells by regulating many downstream genes, including smooth muscle-specific genes. However, the molecular mechanisms underlying IFNγ-induced inhibition of smooth muscle-specific gene expression remain unclear. In this study, we have shown that serum response factor (SRF), a common transcriptional factor important in cell proliferation, migration, and differentiation, is targeted by IFNγ in a STAT1-dependent manner. We show that the molecular mechanism by which IFNγ regulates SRF is via activation of the 2-5A-RNase L system, which triggers SRF mRNA decay and reduced SRF expression. As a result, decreased SRF expression reduces expression of SRF target genes such as smooth muscle α-actin and smooth muscle myosin heavy chain. Additionally, IFNγ reduced p300 and acetylated histone-3 binding in both smooth muscle α-actin and SRF promoters, epigenetically decreasing smooth muscle α-actin and SRF transcriptional activation. Our data reveal that SRF is a novel IFNγ-regulated gene and further elucidate the molecular pathway between IFNγ, IFNγ-regulated genes, and SRF and its target genes.
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Registered trials
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