SynthesisBMC infectious diseases2010
Predicting sequelae and death after bacterial meningitis in childhood: a systematic review of prognostic studies.
Synthesis in BMC infectious diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
65 citing papers in PubMed, 6 syntheses or guidelines pooled it, 156 citations in OpenAlex.
- TLR9 Rs352140 polymorphism contributes to a decreased risk of bacterial meningitis: evidence from a meta-analysis.Epidemiology and infection · 2020Pooled it
- Association between TLR2 + 2477G/A polymorphism and bacterial meningitis: a meta-analysis.Epidemiology and infection · 2018Pooled it
- Risk factors for necrotizing enterocolitis in neonates: a systematic review of prognostic studies.BMC pediatrics · 2017Pooled it
- Methodological issues and recommendations for systematic reviews of prognostic studies: an example from cardiovascular disease.Systematic reviews · 2014Pooled it
- Pooled it
- Risk factors associated with the outcomes of pediatric bacterial meningitis: a systematic review.Jornal de pediatriaPooled it
- Development and internal validation of a prognostic nomogram for poor outcomes in neonatal bacterial meningitis.Translational pediatrics · 2026Article
- Data pipeline quality: development and validation of a quality assessment tool for data-driven algorithms and artificial intelligence in healthcare.BMJ health & care informatics · 2026Article
- Article
- Time to death and its predictors among neonates with seizure in North West Ethiopia.Scientific reports · 2025Article
- Identifying the need for surgical intervention in pediatric bacterial meningitis: single-center experience.Frontiers in pediatrics · 2025Article
- Self-Reported Executive Functioning in Young Adult Survivors of Childhood Bacterial Meningitis.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2024Article
- Article
- Frequency, risk factors, and outcome of neonatal meningitis in sepsis.Pakistan journal of medical sciences · 2024Article
- Determine the factors affecting the time to recovery of children with bacterial meningitis at Jigjiga university referral hospital in the Somali Regional State of Ethiopia: using the parametric shared frailty and AFT models.BMC research notes · 2024Article
- Peripheral white blood cell patterns in children with hydrocephalus as a response to ventriculo-peritoneal shunt infection.PloS one · 2024Article
- Practice patterns in pediatric infectious encephalopathy in four centers in Africa.Frontiers in pediatrics · 2024Article
- Characteristics and prognostic factors of bacterial meningitis in the intensive care unit: a prospective nationwide cohort study.Annals of intensive care · 2023Article
- Article
- High-risk factors associated with refractory childhood bacterial meningitis in Southwest China.BMC pediatrics · 2023Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBacterial meningitis (BM) is a severe infection responsible for high mortality and disabling sequelae. Early identification of patients at high risk of these outcomes is necessary to prevent their occurrence by adequate treatment as much as possible. For this reason, several prognostic models have been developed. The objective of this study is to summarize the evidence regarding prognostic factors predicting death or sequelae due to BM in children 0-18 years of age.
methodsA search in MEDLINE and EMBASE was conducted to identify prognostic studies on risk factors for mortality and sequelae after BM in children. Selection of abstracts, full-text articles and assessment of methodological quality using the QUIPS checklist was performed by two reviewers independently. Data on prognostic factors per outcome were summarized.
resultsOf the 31 studies identified, 15 were of moderate to high quality. Due to substantial heterogeneity in study characteristics and evaluated prognostic factors, no quantitative analysis was performed. Prognostic factors found to be statistically significant in more than one study of moderate or high quality are: complaints > 48 hours before admission, coma/impaired consciousness, (prolonged duration of) seizures, (prolonged) fever, shock, peripheral circulatory failure, respiratory distress, absence of petechiae, causative pathogen Streptococcus pneumoniae, young age, male gender, several cerebrospinal fluid (CSF) parameters and white blood cell (WBC) count.
conclusionsAlthough several important prognostic factors for the prediction of mortality or sequelae after BM were identified, the inability to perform a pooled analysis makes the exact (independent) predictive value of these factors uncertain. This emphasizes the need for additional well-conducted prognostic studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.