ArticleOtology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology2010
Optical coherence tomography of cholesteatoma.
Article in Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- Quantitative Pneumatic Otoscopy Using a Light-Based Ranging Technique.Journal of the Association for Research in Otolaryngology : JARO · 2017Trial
- Tartrazine clearing of the tympanic membrane for improved visualization of the middle ear.Biomedical optics express · 2026Article
- Precise ablation of cholesteatoma using a 445-nm diode laser.Scientific reports · 2026Article
- Differentiating Causes of Post-Surgical Conductive Hearing Loss with Optical Coherence Tomography Vibrometry.Journal of the Association for Research in Otolaryngology : JARO · 2026Article
- Flexible catheter optical coherence tomography of the porcine middle ear via the Eustachian tube using a 3D-printed reflective objective.Journal of biomedical optics · 2025Article
- Quantitative measurement of tympanic membrane structure and symmetry with optical coherence tomography in normal human subjects.Journal of biomedical optics · 2025Article
- Optical Coherence Tomography Imaging and Angiography of Skull Base Tumors Presenting as a Middle Ear Mass in Clinic.Diagnostics (Basel, Switzerland) · 2025Article
- Label-Free Optical Technologies for Middle-Ear Diseases.Bioengineering (Basel, Switzerland) · 2024Review
- Geometrically accurate real-time volumetric visualization of the middle ear using optical coherence tomography.Biomedical optics express · 2023Article
- Automated classification of otitis media with OCT: augmenting pediatric image datasets with gold-standard animal model data.Biomedical optics express · 2022Article
- Shortwave infrared otoscopy for diagnosis of middle ear effusions: a machine-learning-based approach.Scientific reports · 2021Article
- Intraoperative use of optical coherence tomography to differentiate normal and diseased thyroid and parathyroid tissues from lymph node and fat.Lasers in medical science · 2021Article
- Article
- Automated classification platform for the identification of otitis media using optical coherence tomography.NPJ digital medicine · 2019Article
- Endoscopic optical coherence tomography with wide field-of-view for the morphological and functional assessment of the human tympanic membrane.Journal of biomedical optics · 2018Article
- Clinical Utility of Intraoperative Tympanomastoidectomy Assessment Using a Surgical Microscope Integrated with an Optical Coherence Tomography.Scientific reports · 2018Article
- Mapping the phase and amplitude of ossicular chain motion using sound-synchronous optical coherence vibrography.Biomedical optics express · 2018Article
- Direct Analysis of Pathogenic Structures Affixed to the Tympanic Membrane during Chronic Otitis Media.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2018Article
- Noninvasive depth-resolved optical measurements of the tympanic membrane and middle ear for differentiating otitis media.The Laryngoscope · 2015Article
- Optical coherence tomography for the diagnosis and evaluation of human otitis media.Journal of Korean medical science · 2015Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectivesTo image cholesteatoma using optical coherence tomography (OCT) and correlate the results with clinical findings and conventional observations obtained using binocular microscopy and histology. OCT is a high-resolution optical imaging modality that generates cross-sectional images of turbid media, such as tissue with resolution approaching that of light microscopy. OCT relies on intrinsic differences in tissue optical properties for image contrast. STUDY
designIn vivo prospective clinical study.
settingUniversity Medical Center. PATIENTS: Patients with cholesteatoma undergoing otologic surgery.
interventionUsing a commercial OCT imaging system, we obtained cross-sectional images (resolution, approximately 10 microm; depth penetration, approximately 1 mm) of cholesteatomas.
main outcome measuresImages are obtained by raster scanning a single mode fiber across the interior of the probe. The imaging probe is sterilized and inserted into the middle ear or mastoid under microscopic guidance, and still images of the middle ear or mastoid mucosa and cholesteatoma when present were obtained.
resultsOCT images of cholesteatomas demonstrate differences in signal intensity, which are distinct from those of normal or inflamed middle ear/mastoid mucosa. Identification of keratin in cholesteatoma, even if very thin, distinguished it from inflamed mucosa.
conclusionThis is the first study that systematically used OCT to image cholesteatoma during otologic surgery. Cholesteatomas can be distinguished from normal or inflamed adjacent mucosa.
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