ArticleHepatology (Baltimore, Md.)2010
Evaluation of depression as a risk factor for treatment failure in chronic hepatitis C.
Article in Hepatology (Baltimore, Md.), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 97 citations in OpenAlex.
- Antidepressant prophylaxis reduces depression risk but does not improve sustained virological response in hepatitis C interferon recipients without depression at baseline: a systematic review and meta-analysis.Canadian journal of gastroenterology = Journal canadien de gastroenterologie · 2013Pooled it
- Short interferon and ribavirin treatment for HCV genotype 2 or 3 infection: NORDynamIC trial and real-life experience.Scandinavian journal of gastroenterology · 2016Trial
- [Interferon α therapy in patients with chronic hepatitis C infection: biopsychosocial consequences].Der Nervenarzt · 2012Trial
- Peginterferon with or without ribavirin has minimal effect on quality of life, behavioral/emotional, and cognitive outcomes in children.Hepatology (Baltimore, Md.) · 2011Trial
- Direct‑acting antiviral treatment is safe and effective for chronic HCV patients with psychiatric disorders.Experimental and therapeutic medicine · 2023Article
- DEPRESSION, ANXIETY AND QUALITY OF LIFE IN PATIENTS WITH CHRONIC HEPATITIS C VIRUS INFECTION IN VOJVODINA.Acta clinica Croatica · 2021Article
- Association between new-onset liver cirrhosis and suicide risk in South Korea: A nationwide cohort study.Clinical and molecular hepatology · 2021Article
- Hepatitis C virus eradication improves immediate and delayed episodic memory in patients treated with interferon and ribavirin.BMC gastroenterology · 2017Article
- Association of Changes in Mood Status and Psychosocial Well-Being with Depression During Interferon-Based Treatment for Hepatitis C.Psychiatry investigation · 2017Article
- Recurrence of depressive disorders after interferon-induced depression.Translational psychiatry · 2017Article
- Paeoniflorin ameliorates interferon-alpha-induced neuroinflammation and depressive-like behaviors in mice.Oncotarget · 2017Article
- Role of inflammatory cytokines in depression: Focus on interleukin-1β.Biomedical reports · 2017Article
- Depression and Chronic Liver Diseases: Are There Shared Underlying Mechanisms?Frontiers in molecular neuroscience · 2017Review
- Pathogen-Host Defense in the Evolution of Depression: Insights into Epidemiology, Genetics, Bioregional Differences and Female Preponderance.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Review
- Changes in the NMR Metabolic Profile of Live Human Neuron-Like SH-SY5Y Cells Exposed to Interferon-α2.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2016Article
- Hepatitis C virus-associated neurocognitive and neuropsychiatric disorders: Advances in 2015.World journal of gastroenterology · 2015Review
- Personality disorders do not affect treatment outcomes for chronic HCV infection in Spanish prisoners: the Perseo study.BMC infectious diseases · 2015Observational
- Psychiatric and substance use disorders co-morbidities and hepatitis C: Diagnostic and treatment implications.World journal of hepatology · 2015Review
- An Aggravated Trajectory of Depression and Anxiety Co-morbid with Hepatitis C: A Within-groups Study of 61 Australian Outpatients.Clinical practice and epidemiology in mental health : CP & EMH · 2015Article
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Authors and funding
12 authors at 7 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledThe Major Depression Inventory (MDI) was used to estimate the value of routine medical interviews in diagnosing major depression among patients receiving peginterferon alfa-2a and ribavirin therapy for chronic hepatitis C virus (HCV) infection (n = 325). According to criteria from the MDI and Diagnostic and Statistical Manual of Mental Disorders (DSM-IV), 19 patients (6%) had major depression at baseline. An additional 114 (37%) developed depression while on HCV combination therapy, with baseline MDI score and female sex independently predicting the emergence of major depression during treatment in a multivariate analysis. Only 36 (32%) of the 114 patients developing major depression according to MDI/DSM-IV criteria were correctly diagnosed during routine medical interviews. The emergence of major depression frequently led to premature discontinuation of peginterferon/ribavirin therapy, and an on-treatment MDI score increment exceeding 30 points (i.e., a validated marker of idiopathic DSM-IV major depression) was correlated with impaired outcome of HCV therapy (P = 0.02). This difference was even more pronounced among patients with an on-treatment increase in MDI score greater than 35 points (P = 0.003).
conclusionWe conclude that (1) depressive symptoms among patients undergoing HCV therapy are commonly overlooked by routine clinical interviews, (2) the emergence of depression compromises the outcome of HCV therapy, and (3) the MDI scale may be useful in identifying patients at risk for treatment-induced depression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.