Evidence map›Paper›PMID 20683766›Full record

Trial reportJournal of autism and developmental disorders2011

A pilot randomized controlled trial of omega-3 fatty acids for autism spectrum disorder.

Stephen Bent, Kiah Bertoglio, Paul Ashwood, Alan Bostrom, Robert L Hendren

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of autism and developmental disorders, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 11 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 11 syntheses or guidelines pooled it, 153 citations in OpenAlex.

  1. Pooled it
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  5. AUTISM SPECTRUM DISORDER: A SYSTEMATIC REVIEW ABOUT NUTRITIONAL INTERVENTIONS.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2020
    Pooled it
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  11. Omega-3 fatty acids supplementation for autism spectrum disorders (ASD).The Cochrane database of systematic reviews · 2011
    Pooled it
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  20. Change in plasma cytokine levels during risperidone treatment in children with autism.Journal of child and adolescent psychopharmacology · 2014
    Trial

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Stephen BentOsher Center for Integrative Medicine, Department of Medicine, University of California, San Francisco VAMC, 111-A1, 4150 Clement St., San Francisco, CA 94121, USA. Stephen.Bent@ucsf.edu
Kiah Bertoglio
Paul Ashwood
Alan Bostrom
Robert L Hendren
University of California, Davis · USSan Francisco VA Medical Center · USUniversity of California, San Francisco · US

Funding

UCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2M
Autism Speaks AS2311NCRR NIH HHS UL1 RR024131
6 · The paper itself

Abstract

We conducted a pilot randomized controlled trial to determine the feasibility and initial safety and efficacy of omega-3 fatty acids (1.3 g/day) for the treatment of hyperactivity in 27 children ages 3-8 with autism spectrum disorder (ASD). After 12 weeks, hyperactivity, as measured by the Aberrant Behavior Checklist, improved 2.7 (± 4.8) points in the omega-3 group compared to 0.3 (± 7.2) points in the placebo group (p = 0.40; effect size = 0.38). Correlations were found between decreases in five fatty acid levels and decreases in hyperactivity, and the treatment was well tolerated. Although this pilot study did not find a statistically significant benefit from omega-3 fatty acids, the small sample size does not rule out small to moderate beneficial effects.

Indexed as

ChildChild Development Disorders, PervasiveChild, PreschoolFatty Acids, Omega-3FemaleHumansHyperkinesisMalePilot ProjectsTreatment OutcomeFatty Acids, Omega-3

Identifiers

PMID20683766
PMCPMC3076562
OpenAlexW2009214635

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.