ArticleCurrent rheumatology reports2010
Remarkable polymorphism of HLA-B27: an ongoing saga.
Article in Current rheumatology reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Biologic and targeted synthetic therapies in ankylosing spondylitis: a pharmacological review.Frontiers in pharmacology · 2026Review
- Fifty years after the discovery of the association of HLA B27 with ankylosing spondylitis.RMD open · 2023Article
- The Genetics of Spondyloarthritis.Journal of personalized medicine · 2020Review
- Allelic association with ankylosing spondylitis fails to correlate with human leukocyte antigen B27 homodimer formation.The Journal of biological chemistry · 2019Article
- Characteristics of late-onset spondyloarthritis in Japan: A retrospective cohort study.Medicine · 2019Article
- A Single Nucleotide Polymorphism in the Il17ra Promoter Is Associated with Functional Severity of Ankylosing Spondylitis.PloS one · 2016Article
- Polymorphism of HLA-B27: 105 subtypes currently known.Current rheumatology reports · 2013Review
- Ankylosing spondylitis: Chinese perspective, clinical phenotypes, and associated extra-articular systemic features.Current rheumatology reports · 2013Review
- An update on the genetics of HLA B27-associated acute anterior uveitis.Ocular immunology and inflammation · 2011Review
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Histocompatibility antigen HLA-B27 is a normal gene that is distributed worldwide with variable prevalence and shows a remarkable association with ankylosing spondylitis and related spondyloarthropathies. The precise biological explanation for this remarkable association remains elusive. HLA-B27 represents a family of closely related proteins encoded by an ever-increasing number of alleles; there are 75 alleles of HLA-B27 known thus far, based on nucleotide sequence differences, but at the translated protein level, there are 62 known subtypes of HLA-B27. Not all subtypes are disease associated. Moreover, existence of a possible hierarchical ranking among some of the subtypes for their disease association has been observed.
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Registered trials
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