ArticlePediatric nephrology (Berlin, Germany)2010
Urinary monocyte chemoattractant protein-1 correlates with disease activity in lupus nephritis.
Article in Pediatric nephrology (Berlin, Germany), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Association of MCP-1-2518A/G polymorphism with susceptibility to autoimmune diseases: a meta-analysis.Clinical rheumatology · 2016Pooled it
- Meta-analysis of MCP-1 promoter -2518 A/G polymorphism and SLE susceptibility.Molecular biology reports · 2012Pooled it
- Urinary Biomarkers for Lupus Nephritis: A Systems Biology Approach.Journal of clinical medicine · 2024Review
- Low nephron endowment increases susceptibility to renal stress and chronic kidney disease.JCI insight · 2023Article
- Sickle cell nephropathy: A review of novel biomarkers and their potential roles in early detection of renal involvement.World journal of clinical pediatrics · 2022Review
- Proteomic profiling of urine: implications for lupus nephritis.Expert review of proteomics · 2019Review
- Rapid detection of urinary soluble intercellular adhesion molecule-1 for determination of lupus nephritis activity.Medicine · 2018Article
- Serum IP-10 is useful for identifying renal and overall disease activity in pediatric systemic lupus erythematosus.Pediatric nephrology (Berlin, Germany) · 2018Article
- Low level of circulating basophil counts in biopsy-proven active lupus nephritis.Clinical rheumatology · 2018Article
- Article
- MCP1 triggers monocyte dysfunctions during abnormal osteogenic differentiation of mesenchymal stem cells in ankylosing spondylitis.Journal of molecular medicine (Berlin, Germany) · 2017Article
- Longitudinal assessment of monocyte chemoattractant protein-1 in lupus nephritis as a biomarker of disease activity.Clinical rheumatology · 2016Article
- A discrete cluster of urinary biomarkers discriminates between active systemic lupus erythematosus patients with and without glomerulonephritis.Arthritis research & therapy · 2016Article
- Chemokines and Chemokine Receptors in the Development of Lupus Nephritis.Mediators of inflammation · 2016Review
- Impaired B cell inhibition by lupus bone marrow mesenchymal stem cells is caused by reduced CCL2 expression.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- A study of hepcidin and monocyte chemoattractant protein-1 in Egyptian females with systemic lupus erythematosus.Journal of clinical laboratory analysis · 2014Article
- Yin and Yang of PDGF-mediated signaling pathway in the context of HIV infection and drug abuse.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2014Review
- Urine biomarkers for monitoring juvenile lupus nephritis: a prospective longitudinal study.Pediatric nephrology (Berlin, Germany) · 2014Article
- Measuring eosinophiluria, urinary eosinophil cationic protein and urinary interleukin-5 in patients with Lupus Nephritis.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2014Article
- Chemokines as potential markers in pediatric renal diseases.Disease markers · 2014Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Monocyte chemoattractant protein-1 (MCP-1) has a pathogenic role in murine lupus nephritis (LN). We recruited 25 pediatric and adolescent systemic lupus erythematosus (SLE) patients from our lupus clinic [13 (52%) patients with LN and 12 (48%) lupus non-nephritis patients] and evaluated their urinary and plasma MCP-1 levels compared to adult and childhood controls. The median age and SLE disease duration of patients were 14.4 and 5.5 years, respectively. LN patients had a higher median renal (p=0.01) British Isles Lupus Assessment Group (BILAG) index, with a tendency for higher total BILAG scores (p=0.2). There were significantly increased urinary MCP-1 levels in the LN patients compared to healthy controls (p<0.001) whose values were significantly higher than lupus non-nephritis children (p<0.004). Urinary MCP-1 levels correlated well with total BILAG scores (r=0.82, p=0.04). There were no differences in plasma MCP-1 levels between SLE patient groups and pediatric controls, although the levels in the childhood controls were elevated compared to those of the adult controls (p<0.04). These results provide evidence of increased urinary--but not plasma--MCP-1 levels in children with LN, which correlates well with SLE disease activity as measured by the BILAG index.
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