ReviewNature reviews. Rheumatology2010
Genetic epidemiology of age-related osteoporosis and its clinical applications.
Review in Nature reviews. Rheumatology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Role of lifestyle factors in mediating the effect of educational attainment on bone mineral density: a Mendelian randomization study.Archives of osteoporosis · 2023Pooled it
- Common Variants in OPG Confer Risk to Bone Mineral Density Variation and Osteoporosis Fractures.Scientific reports · 2017Pooled it
- Quantitative assessment of the associations between MTHFR C677T and A1298C polymorphisms and risk of fractures: a meta-analysis.Molecular biology reports · 2013Pooled it
- Association between vitamin D receptor gene polymorphisms and bone mineral density in Chinese women.Molecular biology reports · 2012Pooled it
- Meta-analysis of gene-based genome-wide association studies of bone mineral density in Chinese and European subjects.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2012Pooled it
- Association between conicity index and osteoporosis/femoral bone mineral density in USA adults : a cross-sectional study based on evidence from the National Health and Nutrition Examination Survey (2005 to 2020).Bone & joint research · 2026Article
- Polygenic risk score-guided personalized osteoporosis screening: a population-based study.BMC medicine · 2026Article
- Causal relationship between Interleukin-27 expression levels and osteoporosis: a bidirectional mendelian randomization study.BMC musculoskeletal disorders · 2024Article
- Identification of osteoporosis genes using family studies.Frontiers in endocrinology · 2024Review
- Epidemiology of Osteoporosis.Indian journal of orthopaedics · 2023Review
- Article
- MicroRNA‑338‑3p regulates age‑associated osteoporosis via targeting PCSK5.Molecular medicine reports · 2021Article
- Historical overview and new directions in bioarchaeological trace element analysis: a review.Archaeological and anthropological sciences · 2021Review
- Interleukin-6: designing specific therapeutics for a complex cytokine.Nature reviews. Drug discovery · 2018Review
- Metabolomic Pathways to Osteoporosis in Middle-Aged Women: A Genome-Metabolome-Wide Mendelian Randomization Study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2018Article
- Loss of Rictor with aging in osteoblasts promotes age-related bone loss.Cell death & disease · 2016Article
- A Candidate Gene Association Study of Bone Mineral Density in an Iranian Population.Frontiers in endocrinology · 2016Article
- Evaluation of common variants in CNR2 gene for bone mineral density and osteoporosis susceptibility in postmenopausal women of Han Chinese.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015Article
- TNFRSF11B gene polymorphisms, bone mineral density, and fractures in Slovak postmenopausal women.Journal of applied genetics · 2015Article
- The influence of vitamin D receptor genetic variants on bone mineral density and osteoporosis in Chinese postmenopausal women.Disease markers · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoporosis is an important and complex disorder that is highly prevalent worldwide. This disease poses a major challenge to modern medicine and its treatment is associated with high costs. Numerous studies have endeavored to decipher the pathogenesis of this disease. The clinical assessment of patients often incorporates information about a family history of osteoporotic fractures. Indeed, the observation of an increased risk of fracture in an individual with a positive parental history of hip fracture provides strong evidence for the heritability of osteoporosis. The onset and progression of osteoporosis are generally controlled by multiple genetic and environmental factors, as well as interactions between them, with rare cases determined by a single gene. In an attempt to identify the genetic markers of complex diseases such as osteoporosis, there has been a move away from traditional linkage mapping studies and candidate gene association studies to higher-density genome-wide association studies. The advent of high-throughput technology enables genotyping of millions of DNA markers in the human genome, and consequently the identification and characterization of causal variants and loci that underlie osteoporosis. This Review presents an overview of the major findings since 2007 and clinical applications of these genome-wide linkage and association studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.