ArticleThe American journal of tropical medicine and hygiene2010
Frequency distribution of antimalarial drug resistance alleles among Plasmodium falciparum isolates from Gezira State, central Sudan, and Gedarif State, eastern Sudan.
Article in The American journal of tropical medicine and hygiene, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Effect of transmission reduction by insecticide-treated bednets (ITNs) on antimalarial drug resistance in western Kenya.PloS one · 2011Trial
- Unraveling Key Chloroquine Resistance-Associated Alleles AmongInfection and drug resistance · 2024Article
- Dynamics and within-host interaction of Theileria lestoquardi and T. ovis among naive sheep in Oman.Scientific reports · 2020Article
- Assessment of Plasmodium falciparum drug resistance molecular markers from the Blue Nile State, Southeast Sudan.Malaria journal · 2020Article
- Antimalarial drug resistance molecular makers of Plasmodium falciparum isolates from Sudan during 2015-2017.PloS one · 2020Article
- Molecular surveillance of putative drug resistance markers of antifolate and artemisinin among importedPathogens and global health · 2019Article
- Cross sectional study to determine chloroquine resistance amongF1000Research · 2018Article
- Article
- Limited artemisinin resistance-associated polymorphisms in Plasmodium falciparum K13-propeller and PfATPase6 gene isolated from Bioko Island, Equatorial Guinea.International journal for parasitology. Drugs and drug resistance · 2016Article
- Assessment of molecular markers for anti-malarial drug resistance after the introduction and scale-up of malaria control interventions in western Kenya.Malaria journal · 2015Article
- Climate change and epidemiology of human parasitosis in Egypt: A review.Journal of advanced research · 2014Review
- Selection of pfdhfr/pfdhps alleles and declining artesunate/sulphadoxine-pyrimethamine efficacy against Plasmodium falciparum eight years after deployment in eastern Sudan.Malaria journal · 2013Article
- Genetic diversity of Plasmodium falciparum and distribution of drug resistance haplotypes in Yemen.Malaria journal · 2013Article
- Drug-resistant malaria in Sudan: A review of evidence and scenarios for the future.Sudanese journal of paediatrics · 2012Review
- Molecular markers of anti-malarial drug resistance in Lahj Governorate, Yemen: baseline data and implications.Malaria journal · 2011Article
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Authors and funding
10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
In 2004, Sudan adopted artesunate + sulfadoxine/pyrimethamine (SP) combination as the first-line drug, in response to the high level of falciparum resistance to antimalarials. In 2007, a molecular study on antimalarial resistance linked genes, pfcrt, pfmdr1, pfdhfr, pfdhps, and pfATPase6, was conducted on 198 isolates from central and eastern Sudan. We observed a high frequency of point mutations at almost all loci analyzed, mainly of pfcrt 76T (72.7%), pfdhfr 51I (75.3%), and pfdhfr 108N (72.7%) alleles. The MARK III in vitro test for chloroquine sensitivity in 45 P. falciparum isolates showed that 37.8% of the isolates were low resistant and 6.7% were fully resistant. This study represents the most recent molecular investigation on antimalarial resistance in this area after the adoption of artemisinin-based combination therapy (ACT), and underlines the importance of the analysis of SP resistance evolution to monitor the efficacy of ACT therapy in endemic areas.
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