ArticlePhysiological genomics2010
Circadian variations in gene expression in rat abdominal adipose tissue and relationship to physiology.
Article in Physiological genomics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 55 citations in OpenAlex.
- The Interplay Between Circadian Clocks and the Tumour Microenvironment in Breast Cancer.Cancers · 2026Review
- Hippocampal Leptin Resistance and Cognitive Decline: Mechanisms, Therapeutic Strategies and Clinical Implications.Biomedicines · 2024Review
- Tanycytic transcytosis inhibition disrupts energy balance, glucose homeostasis and cognitive function in male mice.Molecular metabolism · 2024Article
- Sex Inclusion in Transcriptome Studies of Daily Rhythms.Journal of biological rhythms · 2023Article
- Leptin brain entry via a tanycytic LepR-EGFR shuttle controls lipid metabolism and pancreas function.Nature metabolism · 2021Article
- Pathway-level analysis of genome-wide circadian dynamics in diverse tissues in rat and mouse.Journal of pharmacokinetics and pharmacodynamics · 2021Article
- Only time will tell: the interplay between circadian clock and metabolism.Chronobiology international · 2021Review
- Transitioning from Basic toward Systems Pharmacodynamic Models: Lessons from Corticosteroids.Pharmacological reviews · 2020Review
- Circadian clock network desynchrony promotes weight gain and alters glucose homeostasis in mice.Molecular metabolism · 2019Article
- Indirect pharmacodynamic models for responses with circadian removal.Journal of pharmacokinetics and pharmacodynamics · 2019Article
- Leptin and brain-adipose crosstalks.Nature reviews. Neuroscience · 2018Review
- Modeling circadian variability of core-clock and clock-controlled genes in four tissues of the rat.PloS one · 2018Article
- Daily variation of gene expression in diverse rat tissues.PloS one · 2018Article
- Role of cardiotrophin-1 in the regulation of metabolic circadian rhythms and adipose core clock genes in mice and characterization of 24-h circulating CT-1 profiles in normal-weight and overweight/obese subjects.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- Adipose Clocks: Burning the Midnight Oil.Journal of biological rhythms · 2015Review
- Characterization of leptin receptor gene in Bubalus bubalis and association analysis with body measurement traits.Molecular biology reports · 2015Article
- Effects of High Fat Feeding on Adipose Tissue Gene Expression in Diabetic Goto-Kakizaki Rats.Gene regulation and systems biology · 2015Article
- Shift work and endocrine disorders.International journal of endocrinology · 2015Review
- Circadian Clocks and the Interaction between Stress Axis and Adipose Function.International journal of endocrinology · 2015Review
- Blood transcriptomics: applications in toxicology.Journal of applied toxicology : JAT · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Circadian rhythms occur in all levels of organization from expression of genes to complex physiological processes. Although much is known about the mechanism of the central clock in the suprachiasmatic nucleus, the regulation of clocks present in peripheral tissues as well as the genes regulated by those clocks is still unclear. In this study, the circadian regulation of gene expression was examined in rat adipose tissue. A rich time series involving 54 animals euthanized at 18 time points within the 24-h cycle (12:12 h light-dark) was performed. mRNA expression was examined with Affymetrix gene array chips and quantitative real-time PCR, along with selected physiological measurements. Transcription factors involved in the regulation of central rhythms were examined, and 13 showed circadian oscillations. Mining of microarray data identified 190 probe sets that showed robust circadian oscillations. Circadian regulated probe sets were further parsed into seven distinct temporal clusters, with >70% of the genes showing maximum expression during the active/dark period. These genes were grouped into eight functional categories, which were examined within the context of their temporal expression. Circadian oscillations were also observed in plasma leptin, corticosterone, insulin, glucose, triglycerides, free fatty acids, and LDL cholesterol. Circadian oscillation in these physiological measurements along with the functional categorization of these genes suggests an important role for circadian rhythms in controlling various functions in white adipose tissue including adipogenesis, energy metabolism, and immune regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.