ArticleThe Journal of biological chemistry2010
Association among amyloid plaque, lipid, and creatine in hippocampus of TgCRND8 mouse model for Alzheimer disease.
Article in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 50 citations in OpenAlex.
- Label-Free In Situ Chemical Characterization of Amyloid Plaques in Human Brain Tissues.ACS chemical neuroscience · 2024Article
- Cryo-EM structures of lipidic fibrils of amyloid-β (1-40).Nature communications · 2024Article
- Imaging Amyloid-β Membrane Interactions: Ion-Channel Pores and Lipid-Bilayer Permeability in Alzheimer's Disease.Angewandte Chemie (International ed. in English) · 2023Review
- Imaging Amyloid-β Membrane Interactions: Ion-Channel Pores and Lipid-Bilayer Permeability in Alzheimer's Disease.Angewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2023Review
- Biochemical Alterations in White Matter Tracts of the Aging Mouse Brain Revealed by FTIR Spectroscopy Imaging.Neurochemical research · 2022Article
- Synthesis of human amyloid restricted to liver results in an Alzheimer disease-like neurodegenerative phenotype.PLoS biology · 2021Article
- 3D-visualization of amyloid-β oligomer interactions with lipid membranes by cryo-electron tomography.Chemical science · 2021Article
- The Progress of Label-Free Optical Imaging in Alzheimer's Disease Screening and Diagnosis.Frontiers in aging neuroscience · 2021Review
- Early neurotransmission impairment in non-invasive Alzheimer Disease detection.Scientific reports · 2020Article
- Amyloid-β oligomers have a profound detergent-like effect on lipid membrane bilayers, imaged by atomic force and electron microscopy.The Journal of biological chemistry · 2019Article
- In situ characterization of protein aggregates in human tissues affected by light chain amyloidosis: a FTIR microspectroscopy study.Scientific reports · 2016Article
- Mechanisms of murine cerebral malaria: Multimodal imaging of altered cerebral metabolism and protein oxidation at hemorrhage sites.Science advances · 2015Article
- Novel bio-spectroscopic imaging reveals disturbed protein homeostasis and thiol redox with protein aggregation prior to hippocampal CA1 pyramidal neuron death induced by global brain ischemia in the rat.Free radical biology & medicine · 2015Article
- Plaque-associated lipids in Alzheimer's diseased brain tissue visualized by nonlinear microscopy.Scientific reports · 2015Article
- In situ biospectroscopic investigation of rapid ischemic and postmortem induced biochemical alterations in the rat brain.ACS chemical neuroscience · 2015Article
- Effects of creatine supplementation on learning, memory retrieval, and apoptosis in an experimental animal model of Alzheimer disease.Medical journal of the Islamic Republic of Iran · 2015Article
- The expression of apoptosis inducing factor (AIF) is associated with aging-related cell death in the cortex but not in the hippocampus in the TgCRND8 mouse model of Alzheimer's disease.BMC neuroscience · 2014Article
- Formation of dynamic soluble surfactant-induced amyloid β peptide aggregation intermediates.The Journal of biological chemistry · 2013Article
- FTIR imaging of brain tissue reveals crystalline creatine deposits are an ex vivo marker of localized ischemia during murine cerebral malaria: general implications for disease neurochemistry.ACS chemical neuroscience · 2012Article
- Exploring the binding of BACE-1 inhibitors using comparative binding energy analysis (COMBINE).BMC structural biology · 2012Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Amyloid peptide (Aβ) aggregation in the brain is a characteristic feature of Alzheimer disease (AD). Previously, we reported the discovery of focally elevated creatine deposits in brain tissue from TgCRND8 mice, which express double mutant (K670N/M671L and V717F) amyloid protein precursor. In this study, frozen hippocampal tissue sections from 5-, 8-, 11-, 14-, and 17-month old TgCRND8 and littermate control mice were examined with Fourier transform infrared microspectroscopy to explore the distribution of lipid, creatine, and dense core plaque deposits. Lipid distribution throughout the hippocampus was similar in transgenic (Tg) and non-Tg littermates at all ages. Dense core plaques were always found to lie within a thin (30-50 μm) lipid envelope, confirmed by imaging through serial sections. Creatine deposits were found in all TgCRND8 mice; the extent of deposition increased with age. Minor creatine deposits appeared in the oldest littermate controls. Distribution in the serial sections showed moderate correlation between layers, slightly disturbed by the freeze/thaw process. Creatine deposits in Tg mice were not specifically co-localized with plaques or lipid halos. The dimension of the lipid envelope is comparable with that of the diffuse halo of nonaggregated amyloid, implying a dynamic association in vivo, postulated to have a significant role in the evolving neurotoxicity.
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