ArticleCell stem cell2010
Getting to the heart of the matter: direct reprogramming to cardiomyocytes.
Article in Cell stem cell, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Stem cell therapy: a paradigm shift in reversing type 1 diabetes mellitus.Annals of medicine and surgery (2012) · 2025Review
- Direct reprogramming of fibroblasts into cardiomyocytes.Stem cell research & therapy · 2017Review
- Somatic Cell Reprogramming into Cardiovascular Lineages.Journal of cardiovascular pharmacology and therapeutics · 2014Article
- Perspective for special Gurdon issue for differentiation: can cell fusion inform nuclear reprogramming?Differentiation; research in biological diversity · 2014Article
- In vivo cardiac cellular reprogramming efficacy is enhanced by angiogenic preconditioning of the infarcted myocardium with vascular endothelial growth factor.Journal of the American Heart Association · 2012Article
- Cardiac cell therapy: the next (re)generation.Stem cell reviews and reports · 2011Article
- Present state and future perspectives of using pluripotent stem cells in toxicology research.Archives of toxicology · 2011Review
- In vivo combinatory gene therapy synergistically promotes cardiac function and vascular regeneration following myocardial infarction.Journal of tissue engineeringArticle
- Control of Stochastic and Induced Switching in Biophysical Networks.Physical review. XArticle
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since MyoD was used to convert fibroblasts directly to skeletal muscle, biologists have tried to apply this strategy to generate other cell lineages. In their recent Cell paper, Ieda et al. (2010) use selected cardiac transcription factors to directly reprogram fibroblasts to cardiomyocytes without passing through an intervening pluripotent state.
Identifiers
20682439What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.