ArticleNeurobiology of disease2010
Receptors with low affinity for neurosteroids and GABA contribute to tonic inhibition of granule cells in epileptic animals.
Article in Neurobiology of disease, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 70 citations in OpenAlex.
- Molecular mechanisms of neurosteroids in temporal lobe epilepsy: current insights and therapeutic perspectives.Molecular biology reports · 2025Review
- Status epilepticus: Updates on mechanisms and treatments.Epilepsia open · 2025Review
- γ-Aminobutyric acid transporter and GABABrain communications · 2024Article
- Neuronal plasticity contributes to postictal death.Progress in neurobiology · 2023Article
- In the fast lane: Receptor trafficking during status epilepticus.Epilepsia open · 2023Review
- Virally-induced expression of GABAProgress in neurobiology · 2022Article
- Long-Term Effects of Moderate Concussive Brain Injury During Adolescence on Synaptic and Tonic GABA Currents in Dentate Granule Cells and Semilunar Granule Cells.Frontiers in neuroscience · 2022Article
- Increased Voluntary Alcohol Consumption in Mice Lacking GABAFrontiers in behavioral neuroscience · 2022Article
- Tonic GABAThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Tonic GABAergic inhibition, via GABAThe European journal of neuroscience · 2021Article
- Progesterone modulates neuronal excitability bidirectionally.Neuroscience letters · 2021Review
- Neurosteroids and Focal Epileptic Disorders.International journal of molecular sciences · 2020Review
- Reduced neurosteroid potentiation of GABAAnnals of clinical and translational neurology · 2020Article
- Astrocytic GABA Accumulation in Experimental Temporal Lobe Epilepsy.Frontiers in neurology · 2020Article
- Neurosteroid regulation of GABABrain research · 2019Review
- Decreased surface expression of the δ subunit of the GABAExperimental neurology · 2017Article
- Anticonvulsive evaluation of THIP in the murine pentylenetetrazole kindling model: lack of anticonvulsive effect of THIP despite functional δ-subunit-containing GABAPharmacology research & perspectives · 2017Article
- Neurosteroid-sensitive δ-GABAEpilepsia · 2017Article
- Tonic GABAA Receptors as Potential Target for the Treatment of Temporal Lobe Epilepsy.Molecular neurobiology · 2016Review
- Seizure-related regulation of GABAA receptors in spontaneously epileptic rats.Neurobiology of disease · 2015Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Neurosteroid sensitivity of GABA(A) receptor mediated inhibition of the hippocampal dentate granule cells (DGCs) is reduced in animal models of temporal lobe epilepsy. However, the properties and subunit composition of GABA(A) receptors mediating tonic inhibition in DGCs of epileptic animals have not been described. In the DGCs of epileptic animals, allopregnanolone and L-655708 sensitivity of holding current was diminished and δ subunit was retained in the endoplasmic reticulum and its surface expression was decreased the in the hippocampus. Ro15-4513 and lanthanum had distinct effects on holding current recorded from DGCs of control and epileptic animals suggesting that the pharmacological properties of GABA(A) receptors maintaining tonic inhibition in DGCs of epileptic animals were similar to those containing the α4βxγ2 subunits. Furthermore, surface expression of the α4 subunit increased and a larger fraction of the subunit co-immunoprecipitated with theγ2 subunit in hippocampi of epileptic animals. Together, these studies revealed that functional α4βxδ and α5βxγ2 receptors were reduced in the hippocampi of epileptic animals and that novel α4bxγ2 receptors contributed to the maintenance of tonic inhibition. The presence of α4βxγ2 receptors resulted in low GABA affinity and neurosteroid sensitivity of tonic currents in the DGCs of epileptic animals that could potentially increase seizure vulnerability. These receptors may represent a novel therapeutic target for anticonvulsant drugs without sedative actions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.