ArticleArchives of biochemistry and biophysics2010
Aggregation modulating elements in mutant human superoxide dismutase 1.
Article in Archives of biochemistry and biophysics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Current and future applications of induced pluripotent stem cell-based models to study pathological proteins in neurodegenerative disorders.Molecular psychiatry · 2021Review
- AAV2/9-mediated overexpression of MIF inhibits SOD1 misfolding, delays disease onset, and extends survival in mouse models of ALS.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Transgenic and physiological mouse models give insights into different aspects of amyotrophic lateral sclerosis.Disease models & mechanisms · 2019Review
- Relationship between mutant Cu/Zn superoxide dismutase 1 maturation and inclusion formation in cell models.Journal of neurochemistry · 2017Article
- A novel mechanism of "metal gel-shift" by histidine-rich Ni2+-binding Hpn protein from Helicobacter pylori strain SS1.PloS one · 2017Article
- Solid-state NMR studies of metal-free SOD1 fibrillar structures.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2014Article
- Conformational specificity of the C4F6 SOD1 antibody; low frequency of reactivity in sporadic ALS cases.Acta neuropathologica communications · 2014Article
- Analysis of mutant SOD1 electrophoretic mobility by Blue Native gel electrophoresis; evidence for soluble multimeric assemblies.PloS one · 2014Article
- An analysis of interactions between fluorescently-tagged mutant and wild-type SOD1 in intracellular inclusions.PloS one · 2013Article
- Fibrillation precursor of superoxide dismutase 1 revealed by gradual tuning of the protein-folding equilibrium.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Abnormal SDS-PAGE migration of cytosolic proteins can identify domains and mechanisms that control surfactant binding.Protein science : a publication of the Protein Society · 2012Article
- Role of disulfide cross-linking of mutant SOD1 in the formation of inclusion-body-like structures.PloS one · 2012Article
- SOD1 and TDP-43 animal models of amyotrophic lateral sclerosis: recent advances in understanding disease toward the development of clinical treatments.Mammalian genome : official journal of the International Mammalian Genome Society · 2011Review
- Structures of mouse SOD1 and human/mouse SOD1 chimeras.Archives of biochemistry and biophysics · 2010Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Mutations in superoxide dismutase 1 (SOD1) cause some forms of familial amyotrophic lateral sclerosis (fALS). Affected tissues of patients and transgenic mouse models of the disease accumulate misfolded and aggregated forms of the mutant protein. In the present study we have identified specific sequences in human SOD1 that modulate the aggregation of fALS mutant proteins. From our study of a panel of mutant proteins, we identify two sequence elements in human SOD1 (residues 42-50 and 109-123) that are critical in modulating the aggregation of the protein. These sequences are components of the 4th and 7th β-strands of the protein, and in the native structure are normally juxtaposed as elements of the core β-barrel. Our data suggest that some type of intermolecular interaction between these elements may occur in promoting mutant SOD1 aggregation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.