ArticleBiophysical journal2010
Curling and local shape changes of red blood cell membranes driven by cytoskeletal reorganization.
Article in Biophysical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 49 citations in OpenAlex.
- Curvature-Assisted Vesicle Explosion Under Light-Induced Asymmetric Oxidation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Proteomes of plasmodium knowlesi early and late ring-stage parasites and infected host erythrocytes.Journal of proteomics · 2024Article
- Effective cell membrane tension protects red blood cells against malaria invasion.PLoS computational biology · 2023Article
- Biophysical Tools and Concepts Enable Understanding of Asexual Blood Stage Malaria.Frontiers in cellular and infection microbiology · 2022Review
- Red Blood Cell Extracellular Vesicle-Based Drug Delivery: Challenges and Opportunities.Frontiers in medicine · 2021Review
- Host Cytoskeleton Remodeling throughout the Blood Stages of Plasmodium falciparum.Microbiology and molecular biology reviews : MMBR · 2019Review
- The noisy basis of morphogenesis: Mechanisms and mechanics of cell sheet folding inferred from developmental variability.PLoS biology · 2018Article
- Contribution of plasma membrane lipid domains to red blood cell (re)shaping.Scientific reports · 2017Article
- The mechanical properties of stored red blood cells measured by a convenient microfluidic approach combining with mathematic model.Biomicrofluidics · 2016Article
- Role of band 3 in the erythrocyte membrane structural changes under thermal fluctuations -multi scale modeling considerations.Journal of bioenergetics and biomembranes · 2015Review
- Dynamic morphology and cytoskeletal protein changes during spontaneous inside-out vesiculation of red blood cell membranes.Pflugers Archiv : European journal of physiology · 2014Article
- The degree of resistance of erythrocyte membrane cytoskeletal proteins to supra-physiologic concentrations of calcium: an in vitro study.The Journal of membrane biology · 2014Article
- Membrane-wrapping contributions to malaria parasite invasion of the human erythrocyte.Biophysical journal · 2014Article
- Dynamics and instabilities of lipid bilayer membrane shapes.Advances in colloid and interface science · 2014Review
- Erythrocyte stiffness during morphological remodeling induced by carbon ion radiation.PloS one · 2014Article
- Red blood cell membrane dynamics during malaria parasite egress.Biophysical journal · 2012Article
- Morphological alterations of T24 cells on flat and nanotubular TiO2 surfaces.Croatian medical journal · 2012Article
- Exploring the binding dynamics of BAR proteins.Cellular & molecular biology letters · 2011Article
- Membrane stress tensor in the presence of lipid density and composition inhomogeneities.The European physical journal. E, Soft matter · 2011Article
- Theoretical model for cellular shapes driven by protrusive and adhesive forces.PLoS computational biology · 2011Article
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
Human red blood cells (RBCs) lack the actin-myosin-microtubule cytoskeleton that is responsible for shape changes in other cells. Nevertheless, they can display highly dynamic local deformations in response to external perturbations, such as those that occur during the process of apical alignment preceding merozoite invasion in malaria. Moreover, after lysis in divalent cation-free media, the isolated membranes of ruptured ghosts show spontaneous inside-out curling motions at the free edges of the lytic hole, leading to inside-out vesiculation. The molecular mechanisms that drive these rapid shape changes are unknown. Here, we propose a molecular model in which the spectrin filaments of the RBC cortical cytoskeleton control the sign and dynamics of membrane curvature depending on whether the ends of the filaments are free or anchored to the bilayer. Computer simulations of the model reveal that curling, as experimentally observed, can be obtained either by an overall excess of weakly-bound filaments throughout the cell, or by the flux of such filaments toward the curling edges. Divalent cations have been shown to arrest the curling process, and Ca2+ ions have also been implicated in local membrane deformations during merozoite invasion. These effects can be replicated in our model by attributing the divalent cation effects to increased filament-membrane binding. This process converts the curl-inducing loose filaments into fully bound filaments that arrest curling. The same basic mechanism can be shown to account for Ca2+-induced local and dynamic membrane deformations in intact RBCs. The implications of these results in terms of RBC membrane dynamics under physiological, pathological, and experimental conditions is discussed.
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