ArticleBiophysical journal2010
Providing positional information with active transport on dynamic microtubules.
Article in Biophysical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- Both sides now: modeling motor regulation of microtubule length at both ends.Physical biology · 2026Article
- Emergent microtubule properties in a model of filament turnover and nucleation.Journal of theoretical biology · 2026Article
- Article
- Metaphase kinetochore movements are regulated by kinesin-8 motors and microtubule dynamic instability.Molecular biology of the cell · 2018Article
- Polymerisation force of a rigid filament bundle: diffusive interaction leads to sublinear force-number scaling.Scientific reports · 2018Article
- Phase-plane analysis of the totally asymmetric simple exclusion process with binding kinetics and switching between antiparallel lanes.Physical review. E · 2016Article
- Motor Protein Accumulation on Antiparallel Microtubule Overlaps.Biophysical journal · 2016Article
- Delayed feedback model of axonal length sensing.Biophysical journal · 2015Article
- Feedback mechanism for microtubule length regulation by stathmin gradients.Biophysical journal · 2014Article
- Biophysics of filament length regulation by molecular motors.Physical biology · 2013Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microtubules (MTs) are dynamic protein polymers that change their length by switching between growing and shrinking states in a process termed dynamic instability. It has been suggested that the dynamic properties of MTs are central to the organization of the eukaryotic intracellular space, and that they are involved in the control of cell morphology, but the actual mechanisms are not well understood. Here, we present a theoretical analysis in which we explore the possibility that a system of dynamic MTs and MT end-tracking molecular motors is providing specific positional information inside cells. We compute the MT length distribution for the case of MT-length-dependent switching between growing and shrinking states, and analyze the accumulation of molecular motors at the tips of growing MTs. Using these results, we show that a transport system consisting of dynamic MTs and associated motor proteins can deliver cargo proteins preferentially to specific positions within the cell. Comparing our results with experimental data in the model organism fission yeast, we propose that the suggested mechanisms could play important roles in setting length scales during cellular morphogenesis.
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