ArticleBreast cancer research : BCR2010
Breast cancer incidence and overdiagnosis in Catalonia (Spain).
Article in Breast cancer research : BCR, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Quantifying and monitoring overdiagnosis in cancer screening: a systematic review of methods.BMJ (Clinical research ed.) · 2015Pooled it
- Feasibility and acceptability of personalised breast cancer screening (DECIDO study): protocol of a single-arm proof-of-concept trial.BMJ open · 2020Article
- Change in mammographic density across birth cohorts of Dutch breast cancer screening participants.International journal of cancer · 2019Article
- Use of Mastectomy for Overdiagnosed Breast Cancer in the United States: Analysis of the SEER 9 Cancer Registries.Journal of cancer epidemiology · 2019Article
- Long-term crude probabilities of death among breast cancer patients by age and stage: a population-based survival study in Northeastern Spain (Girona-Tarragona 1985-2004).Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2018Article
- Assessing predicted age-specific breast cancer mortality rates in 27 European countries by 2020.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2018Article
- The fluctuating incidence, improved survival of patients with breast cancer, and disparities by age, race, and socioeconomic status by decade, 1981-2010.Cancer management and research · 2018Article
- Overdiagnosis: epidemiologic concepts and estimation.Epidemiology and health · 2015Article
- Breast and prostate cancer: an analysis of common epidemiological features in mortality trends in Spain.BMC cancer · 2014Article
- Were our estimates of overdiagnosis with mammography screening in the United States "based on faulty science"?The oncologist · 2014Article
- Cost-effectiveness and harm-benefit analyses of risk-based screening strategies for breast cancer.PloS one · 2014Article
- Immediate and delayed effects of mammographic screening on breast cancer mortality and incidence in birth cohorts.British journal of cancer · 2013Article
- The benefits and harms of breast cancer screening: an independent review.British journal of cancer · 2013Review
- Contribution of early detection and adjuvant treatments to breast cancer mortality reduction in Catalonia, Spain.PloS one · 2012Article
- An investigation of the apparent breast cancer epidemic in France: screening and incidence trends in birth cohorts.BMC cancer · 2011Article
- The breast screening programme and misinforming the public.Journal of the Royal Society of Medicine · 2011Review
- Article
- Interpreting overdiagnosis estimates in population-based mammography screening.Epidemiologic reviews · 2011Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionEarly detection of breast cancer (BC) with mammography may cause overdiagnosis and overtreatment, detecting tumors which would remain undiagnosed during a lifetime. The aims of this study were: first, to model invasive BC incidence trends in Catalonia (Spain) taking into account reproductive and screening data; and second, to quantify the extent of BC overdiagnosis.
methodsWe modeled the incidence of invasive BC using a Poisson regression model. Explanatory variables were: age at diagnosis and cohort characteristics (completed fertility rate, percentage of women that use mammography at age 50, and year of birth). This model also was used to estimate the background incidence in the absence of screening. We used a probabilistic model to estimate the expected BC incidence if women in the population used mammography as reported in health surveys. The difference between the observed and expected cumulative incidences provided an estimate of overdiagnosis.
resultsIncidence of invasive BC increased, especially in cohorts born from 1940 to 1955. The biggest increase was observed in these cohorts between the ages of 50 to 65 years, where the final BC incidence rates more than doubled the initial ones. Dissemination of mammography was significantly associated with BC incidence and overdiagnosis. Our estimates of overdiagnosis ranged from 0.4% to 46.6%, for women born around 1935 and 1950, respectively.
conclusionsOur results support the existence of overdiagnosis in Catalonia attributed to mammography usage, and the limited malignant potential of some tumors may play an important role. Women should be better informed about this risk. Research should be oriented towards personalized screening and risk assessment tools.
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