ReviewInternational journal of experimental pathology2011
Congenital ureteropelvic junction obstruction: human disease and animal models.
Review in International journal of experimental pathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 103 citations in OpenAlex.
- A systematic review of underlying genetic factors associated with ureteropelvic junction obstruction in stenotic human tissue.Journal of pediatric urology · 2022Pooled it
- Ultrasonographic changes following pyeloplasty in children with ureteropelvic junction obstruction: a prospective observational before-after cohort study.Annals of medicine and surgery (2012) · 2026Article
- Correlation of pre-operative sonographic and nuclear scan parameters with intraoperative renal histopathology in children with congenital pelviureteric junction obstruction.International urology and nephrology · 2026Observational
- Article
- Diagnostic yield of urinary tract ultrasound in children following a first urinary tract infection: a retrospective cohort study.Pediatric radiology · 2026Article
- Rethinking Potassium Management in Chronic Kidney Disease-A Modern Approach.Journal of clinical medicine · 2025Review
- Effect of the location and severity of partial ureteral obstruction on urinary system stone disease formation.Scientific reports · 2025Article
- Heterotaxy syndrome, dextrocardia, ureteropelvic obstruction, endometriosis, and pulmonary hypertension in an adult with congenital heart defects: a case report.Journal of medical case reports · 2025Article
- Obstructive uropathy: Overview of the pathogenesis, etiology and management of a prevalent cause of acute kidney injury.World journal of nephrology · 2024Review
- Role of urinary N-acetyl-beta-D-glucosaminidase in predicting the prognosis of antenatal hydronephrosis.Investigative and clinical urology · 2024Article
- Interleukin-10 enhances recruitment of immune cells in the neonatal mouse model of obstructive nephropathy.Scientific reports · 2024Article
- Degree of kidney injury due to artificial pelvic-ureteric junction obstruction with level of neutrophil gelatinase-associated lipocalin, interleukin 18, and histopathological descriptions in Wistar: experimental research.Annals of medicine and surgery (2012) · 2023Article
- Understanding ureteropelvic junction obstruction: how far have we come?Frontiers in urology · 2023Review
- An Adult Case of Severe Asymptomatic Bilateral Ureteropelvic Junction Obstruction.Case reports in nephrology · 2023Article
- MicroRNA-146a-5p-modified human umbilical cord mesenchymal stem cells enhance protection against diabetic nephropathy in rats through facilitating M2 macrophage polarization.Stem cell research & therapy · 2022Article
- Retrospective Analysis of the Efficacy of Da Vinci Robot-Assisted Pyeloplasty in the Treatment of Ureteropelvic Junction Obstruction in Children.Journal of healthcare engineering · 2021Article
- Renal developmental genes are differentially regulated after unilateral ureteral obstruction in neonatal and adult mice.Scientific reports · 2020Article
- A novel urinary biomarker protein panel to identify children with ureteropelvic junction obstruction - A pilot study.Journal of pediatric urology · 2020Article
- Roles Played by Biomarkers of Kidney Injury in Patients with Upper Urinary Tract Obstruction.International journal of molecular sciences · 2020Review
- DTI of the kidney in children: comparison between normal kidneys and those with ureteropelvic junction (UPJ) obstruction.Magma (New York, N.Y.) · 2020Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ureteropelvic junction (UPJ) obstruction is the most frequently observed cause of obstructive nephropathy in children. Neonatal and foetal animal models have been developed that mimic closely what is observed in human disease. The purpose of this review is to discuss how obstructive nephropathy alters kidney histology and function and describe the molecular mechanisms involved in the progression of the lesions, including inflammation, proliferation/apoptosis, renin-angiotensin system activation and fibrosis, based on both human and animal data. Also we propose that during obstructive nephropathy, hydrodynamic modifications are early inducers of the tubular lesions, which are potentially at the origin of the pathology. Finally, an important observation in animal models is that relief of obstruction during kidney development has important effects on renal function later in adult life. A major short-coming is the absence of data on the impact of UPJ obstruction on long-term adult renal function to elucidate whether these animal data are also valid in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.