ArticleThe Journal of infectious diseases2010
Genetic and household determinants of predisposition to human hookworm infection in a Brazilian community.
Article in The Journal of infectious diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Current epidemiological evidence for predisposition to high or low intensity human helminth infection: a systematic review.Parasites & vectors · 2018Pooled it
- Paying Upfront: Successful Initial Infections Protect Against Severe Future Infections.Integrative organismal biology (Oxford, England) · 2026Article
- Sex-Specific Immune Responses Mediate Host Specificity in Hookworm Infections.Tropical medicine and infectious disease · 2025Article
- Parasites and plantations: Disease, environment and society in efforts to induce extinction of hookworm in Jamaica, 1919-1936.Cambridge prisms. Extinction · 2025Article
- Prevalence of Intestinal Parasitic Infections, Genotypes, and Drug Susceptibility ofTropical medicine and infectious disease · 2023Article
- Predisposition to soil-transmitted helminth reinfection after four rounds of mass drug administration: results from a longitudinal cohort in the Geshiyaro project, a transmission elimination feasibility study in the Wolaita zone of southern Ethiopia.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2023Article
- The Influence of Genetic and Environmental Factors and Their Interactions on Immune Response to Helminth Infections.Frontiers in immunology · 2022Review
- Effect of Lymphatic Filariasis and Hookworm Infection on Pregnancy Course and Outcome in Women Living in the Democratic Republic of the Congo.The American journal of tropical medicine and hygiene · 2021Article
- Soil-transmitted helminth reinfection four and six months after mass drug administration: results from the delta region of Myanmar.PLoS neglected tropical diseases · 2019Article
- Particularities of allergy in the Tropics.The World Allergy Organization journal · 2016Review
- Feasibility of controlling hookworm infection through preventive chemotherapy: a simulation study using the individual-based WORMSIM modelling framework.Parasites & vectors · 2015Article
- The Right Tool for the Job: Detection of Soil-Transmitted Helminths in Areas Co-endemic for Other Helminths.PLoS neglected tropical diseases · 2015Article
- Genome of the human hookworm Necator americanus.Nature genetics · 2014Article
- Article
- Regional, household and individual factors that influence soil transmitted helminth reinfection dynamics in preschool children from rural indigenous Panamá.PLoS neglected tropical diseases · 2013Article
- A history of hookworm vaccine development.Human vaccines · 2011Review
- The potential economic value of a hookworm vaccine.Vaccine · 2011Article
- Spatial and genetic epidemiology of hookworm in a rural community in Uganda.PLoS neglected tropical diseases · 2010Article
- Human helminth co-infection: no evidence of common genetic control of hookworm and Schistosoma mansoni infection intensity in a Brazilian community.International journal for parasitology · 2010Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundPredisposition to heavy or light human hookworm infection is consistently reported in treatment-reinfection studies. A significant role for host genetics in determining hookworm infection intensity has also been shown, but the relationship between host genetics and predisposition has not been investigated.
methodsA treatment-reinfection study was conducted among 1302 individuals in Brazil. Bivariate variance components analysis was used to estimate heritability for pretreatment and reinfection intensity and to estimate the contribution of genetic and household correlations between phenotypes to the overall phenotypic correlation (ie, predisposition).
resultsHeritability for hookworm egg count was 17% before treatment and 25% after reinfection. Predisposition to heavy or light hookworm infection was observed, with a phenotypic correlation of 0.34 between pretreatment and reinfection intensity. This correlation was reduced to 0.23 after including household and environmental covariates. Genetic and household correlations were 0.41 and 1, respectively, and explained 88% of the adjusted phenotypic correlation.
conclusionsPredisposition to human hookworm infection in this area results from a combination of host genetics and consistent differences in exposure, with the latter explained by household and environmental factors. Unmeasured individual-specific differences in exposure did not contribute to predisposition.
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