ArticleStem cells (Dayton, Ohio)2010
Fibroblast growth factor type 2 signaling is critical for DNA repair in human keratinocyte stem cells.
Article in Stem cells (Dayton, Ohio), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 36 citations in OpenAlex.
- NDRG2 orchestrates circadian clock stability to suppress tumorigenesis and potentiate oxaliplatin response in colorectal cancer.Oncogene · 2026Article
- Fibroblast growth factor signaling induces a chondrocyte-like state of peripheral nerve fibroblast during aging.Nature communications · 2025Article
- FGF/FGFR signaling pathway involved resistance in various cancer types.Journal of Cancer · 2020Review
- VEGF, FGF-2 and TGFβ expression in the normal and regenerating epidermis of geckos: implications for epidermal homeostasis and wound healing in reptiles.Journal of anatomy · 2018Article
- Staphylococcus aureus Triggers Induction of miR-15B-5P to Diminish DNA Repair and Deregulate Inflammatory Response in Diabetic Foot Ulcers.The Journal of investigative dermatology · 2018Article
- Keratinocyte stem cells are more resistant to UVA radiation than their direct progeny.PloS one · 2018Article
- α6 Integrin (α6International journal of molecular sciences · 2017Article
- Geminin prevents DNA damage in vagal neural crest cells to ensure normal enteric neurogenesis.BMC biology · 2016Article
- Isolation of All CD44 Transcripts in Human Epidermis and Regulation of Their Expression by Various Agents.PloS one · 2016Article
- 1α,25(OH)₂D₃ inhibits FGF-2 release from oral squamous cell carcinoma cells through down-regulation of HBp17/FGFBP-1.In vitro cellular & developmental biology. Animal · 2014Article
- Endothelial cells mitigate DNA damage and promote the regeneration of hematopoietic stem cells after radiation injury.Stem cell research · 2013Article
- FGF2 mediates DNA repair in epidermoid carcinoma cells exposed to ionizing radiation.International journal of radiation biology · 2012Article
- Development and homeostasis of the skin epidermis.Cold Spring Harbor perspectives in biology · 2012Article
- Delayed cell death associated with mitotic catastrophe in γ-irradiated stem-like glioma cells.Radiation oncology (London, England) · 2011Article
- DNA repair: the culprit for tumor-initiating cell survival?Cancer metastasis reviews · 2011Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tissue stem cells must be endowed with superior maintenance and repair systems to ensure genomic stability over multiple generations, which would be less necessary in more differentiated cells. We previously reported that human keratinocyte stem cells were more resistant to ionizing radiation toxicity than their direct progeny, the keratinocyte progenitor cells. In the present study we addressed the mechanisms underlying this difference. Investigations of DNA repair showed that both single and double DNA strand breaks were repaired more rapidly and more efficiently in stem cells than in progenitors. As cell signaling is a key regulatory step in the management of DNA damage, a gene profiling study was performed. Data revealed that several genes of the fibroblast growth factor type 2 (FGF2) signaling pathway were induced by DNA damage in stem cells and not in progenitors. Furthermore, an increased content of the FGF2 protein was found in irradiated stem cells, both for the secreted and the cellular forms of the protein. To examine the role of endogenous FGF2 in DNA repair, stem cells were exposed to FGF2 pathway inhibitors. Blocking the FGF2 receptor (FGF receptor 1) or the kinase (Ras-mitogen-activated protein kinase 1) resulted in a inhibition of single and double DNA strand-break repair in the keratinocyte stem cells. Moreover, supplementing the progenitor cells with exogenous FGF2 activated their DNA repair. We propose that, apart from its well-known role as a strong mitogen and prosurvival factor, FGF2 helps to maintain genomic integrity in stem cells by activating stress-induced DNA repair.
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