ArticleProceedings of the National Academy of Sciences of the United States of America1991
Anionic subsites of the catalytic center of acetylcholinesterase from Torpedo and from cobra venom.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 45 citations in OpenAlex.
- Proteomic Investigations of Two PakistaniToxins · 2020Article
- Malathion, carbofuran and paraquat inhibit Bungarus sindanus (krait) venom acetylcholinesterase and human serum butyrylcholinesterase in vitro.Ecotoxicology (London, England) · 2007Article
- MTD-ADJ: a multiconformational minimal topologic difference for determining bioactive conformers using adjusted biological activities.Journal of computer-aided molecular design · 1998Article
- Identification of amino acid residues involved in the binding of Huperzine A to cholinesterases.Protein science : a publication of the Protein Society · 1994Article
- Substrate inhibition of acetylcholinesterase: residues affecting signal transduction from the surface to the catalytic center.The EMBO journal · 1992Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A peptide of acetylcholinesterase (AcChoEase; acetylcholine acetylhydrolase, EC 3.1.1.7) from the venom of the cobra Naja naja oxiana labeled by the affinity reagent N,N-dimethyl-2-phenylaziridinium (DPA) has been identified. The sequence is Gly-Ala-Glu-Met-Trp-Asn-Pro-Asn. In AcChoEase from Torpedo californica, a homologous peptide was labeled and isolated. Its sequence is Ser-Gly-Ser-Glu-Met-Trp-Asn-Pro-Asn, representing positions 79 through 87. In both cases labeling can be prevented by 0.1 mM edrophonium, indicating that the respective peptides form part of the anionic subsite of the catalytic center. The modified residue was tryptophan (Trp-84 in Torpedo AcChoEase) in both enzymes. In contrast to AcChoEase from Torpedo, the enzyme from cobra venom does not contain a peripheral anionic binding site.
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