ReviewJournal of cardiovascular translational research2010
Small molecule screening in zebrafish.
Review in Journal of cardiovascular translational research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Deletion of theInternational journal of molecular sciences · 2023Article
- Article
- Epithelial delamination is protective during pharmaceutical-induced enteropathy.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Transplantation of Human-Induced Pluripotent Stem Cell-Derived Neural Precursors into Early-Stage Zebrafish Embryos.Journal of molecular neuroscience : MN · 2018Article
- Comparative developmental toxicity of a comprehensive suite of polycyclic aromatic hydrocarbons.Archives of toxicology · 2018Article
- Standardized orthotopic xenografts in zebrafish reveal glioma cell-line-specific characteristics and tumor cell heterogeneity.Disease models & mechanisms · 2016Article
- Strategies for analyzing cardiac phenotypes in the zebrafish embryo.Methods in cell biology · 2016Article
- Identifying Novel Cancer Therapies Using Chemical Genetics and Zebrafish.Advances in experimental medicine and biology · 2016Review
- Efficient transgenesis mediated by pigmentation rescue in zebrafish.BioTechniques · 2016Article
- Zebrafish as a model for leukemia and other hematopoietic disorders.Journal of hematology & oncology · 2015Review
- Zebrafish xenotransplantation model for cancer stem-like cell study and high-throughput screening of inhibitors.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- A manual small molecule screen approaching high-throughput using zebrafish embryos.Journal of visualized experiments : JoVE · 2014Article
- Cessation of contraction induces cardiomyocyte remodeling during zebrafish cardiogenesis.American journal of physiology. Heart and circulatory physiology · 2014Article
- Zebrafish: modeling for herpes simplex virus infections.Zebrafish · 2014Article
- Quantitative phenotyping-based in vivo chemical screening in a zebrafish model of leukemia stem cell xenotransplantation.PloS one · 2014Article
- A chemical screening procedure for glucocorticoid signaling with a zebrafish larva luciferase reporter system.Journal of visualized experiments : JoVE · 2013Article
- The zebrafish model system in cardiovascular research: A tiny fish with mighty prospects.Global cardiology science & practice · 2013Review
- AUTOMATED QUANTIFICATION OF ZEBRAFISH TAIL DEFORMATION FOR HIGH-THROUGHPUT DRUG SCREENING.Proceedings. IEEE International Symposium on Biomedical Imaging · 2013Article
- A chemical screening system for glucocorticoid stress hormone signaling in an intact vertebrate.ACS chemical biology · 2012Article
- Studying synthetic lethal interactions in the zebrafish system: insight into disease genes and mechanisms.Disease models & mechanisms · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Small molecule screens have become useful tools in ongoing efforts to understand complex biologic systems and disease states. These screens can identify compounds that specifically affect signaling pathways, development, and disease processes. The zebrafish Danio rerio has increasingly been used as a whole organism model in which to perform such functional small molecule screens. Here, we review recent advances in screening approaches that focus on modulation of developmental processes and signaling pathways, along with suppressor screens of disease models. The identification of small molecule targets continues to be a challenge, and several recent approaches to this problem are discussed. The promise of chemical screens in zebrafish to identify novel biologic probes and therapeutic compounds continues to drive this rapidly growing field.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.