ArticleActa neurochirurgica2010
Towards improving the safety and diagnostic yield of stereotactic biopsy in a single centre.
Article in Acta neurochirurgica, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 3 of them syntheses that pooled it.
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Who cites it
42 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Clinical outcomes as a function of the number of samples taken during stereotactic needle biopsies: a meta-analysis.Journal of neuro-oncology · 2021Pooled it
- Fluorescein-assisted stereotactic needle biopsy of brain tumors: a single-center experience and systematic review.Neurosurgical review · 2019Pooled it
- The role of biopsy in the management of patients with presumed diffuse low grade glioma: A systematic review and evidence-based clinical practice guideline.Journal of neuro-oncology · 2015Guideline
- Non-diagnostic stereotactic intracranial biopsies: a 15-year institutional experience.Journal of neuro-oncology · 2026Article
- Towards Optical Biopsy in Glioma Surgery.International journal of molecular sciences · 2025Review
- Cell-intrinsic metabolic phenotypes identified in patients with glioblastoma, using mass spectrometry imaging ofNature metabolism · 2025Article
- Evaluation of feasibility accuracy and safety after 79 O-ARM based stereotactic brain biopsies.Scientific reports · 2025Article
- Intraoperative ex-vivo epifluorescent diagnostics of stereotactic brain biopsies using EndoScell scanner: diagnostic accuracy study.Neurosurgical review · 2025Article
- Magnetic resonance-guided stereotactic biopsy in intracranial lesions.Surgical neurology international · 2025Article
- Diagnostic yield of intraoperative frozen sections obtained through robot-assisted stereotactic biopsy of brain lesions.Frontiers in neurology · 2025Article
- Launching Stealth AutoGuideFrontiers in robotics and AI · 2024Article
- Advances in Diagnostic Tools and Therapeutic Approaches for Gliomas: A Comprehensive Review.Sensors (Basel, Switzerland) · 2023Review
- Navigation Guided Biopsy Is as Effective as Frame-Based Stereotactic Biopsy.Journal of personalized medicine · 2023Article
- Computed tomography-guided stereotactic surgery in the management of brain lesions: A single-center experience.Surgical neurology international · 2023Article
- Frameless Stereotactic Biopsy with Intraoperative Computed Tomography "Assessment of Efficacy and Real Target Registration Error".Neurologia medico-chirurgica · 2022Article
- OCT-Guided Surgery for Gliomas: Current Concept and Future Perspectives.Diagnostics (Basel, Switzerland) · 2022Review
- Reassessing the Role of Brain Tumor Biopsy in the Era of Advanced Surgical, Molecular, and Imaging Techniques-A Single-Center Experience with Long-Term Follow-Up.Journal of personalized medicine · 2021Article
- Stereotactic biopsy for lesions in brainstem and deep brain: a single-center experience of 72 cases.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2021Article
- Article
- Multispectral diffuse reflectance can discriminate blood vessels and bleeding during neurosurgery based on low-frequency hemodynamics.Journal of biomedical optics · 2020Article
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundPreviously, we reported on our single centre results regarding the diagnostic yield of stereotactic needle biopsies of brain lesions. The yield then (1996-2006) was 89.4%. In the present study, we review and evaluate our experience with intraoperative frozen-section histopathologic diagnosis on-demand in order to improve the diagnostic yield.
methodsOne hundred sixty-four consecutive frameless biopsy procedures in 160 patients (group 1, 2006-2010) were compared with the historic control group (group 2, n = 164 frameless biopsy procedures). Diagnostic yield, as well as demographics, morbidity and mortality, was compared. Statistical analysis was performed by Student's t, Mann-Whitney U, Chi-square test and backward logistic regression when appropriate.
resultsDemographics were comparable. In group 1, a non-diagnostic tissue specimen was obtained in 1.8%, compared to 11.0% in group 2 (p = 0.001). Also, both the operating time and the number of biopsies needed were decreased significantly. Procedure-related mortality decreased from 3.7% to 0.6% (p = 0.121). Multivariate analysis only proved operating time (odds ratio (OR), 1.012; 95% confidence interval (CI), 1.000-1.025; p = 0.043), a right-sided lesion (OR, 3.183; 95% CI, 1.217-8.322; p = 0.018) and on-demand intraoperative histology (OR, 0.175; 95% CI, 0.050-0.618; p = 0.007) important factors predicting non-diagnostic biopsies.
conclusionsThe importance of a reliable pathological diagnosis as obtained by biopsy must not be underestimated. We believe that when performing stereotactic biopsy for intracranial lesions, next to minimising morbidity, one should strive for as high a positive yield as possible. In the present single centre retrospective series, we have shown that using a standardised procedure and careful on-demand intraoperative frozen-section analysis can improve the diagnostic yield of stereotactic brain biopsy procedures as compared to a historical series.
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