Evidence map›Paper›PMID 20680427›Full record

ArticleJournal of autism and developmental disorders2011

Controlled evaluation of the effects of hyperbaric oxygen therapy on the behavior of 16 children with autism spectrum disorders.

Bryan Jepson, Doreen Granpeesheh, Jonathan Tarbox, Melissa L Olive, Carol Stott, Scott Braud, J Helen Yoo, Andrew Wakefield, Michael S Allen

Abstract readControlled Clinical Trial
PubMed Publisher
In one paragraph

Article in Journal of autism and developmental disorders, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.

  1. Hyperbaric oxygen therapy for people with autism spectrum disorder (ASD).The Cochrane database of systematic reviews · 2016
    Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Hyperbaric oxygen therapy for children with autism spectrum disorder.Canadian family physician Medecin de famille canadien · 2017
    Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Bryan JepsonThoughtful House Center for Children, Austin, TX, USA.
Doreen Granpeesheh
Jonathan Tarbox
Melissa L Olive
Carol Stott
Scott Braud
J Helen Yoo
Andrew Wakefield
Michael S Allen
Center for Autism and Related Disorders · USJohnson Center for Child Health and Development · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hyperbaric oxygen therapy (HBOT) has been used to treat individuals with autism. However, few studies of its effectiveness have been completed. The current study examined the effects of 40 HBOT sessions at 24% oxygen at 1.3 ATA on 11 topographies of directly observed behavior. Five replications of multiple baselines were completed across a total of 16 participants with autism spectrum disorders. No consistent effects were observed across any group or within any individual participant, demonstrating that HBOT was not an effective treatment for the participants in this study. This study represents the first relatively large-scale controlled study evaluating the effects of HBOT at the level of the individual participant, on a wide array of behaviors.

Indexed as

Hyperbaric OxygenationChildChild BehaviorChild Development Disorders, PervasiveChild, PreschoolFemaleHumansMalePatient SelectionTreatment Outcome

Identifiers

PMID20680427
OpenAlexW1998348997

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.