ReviewInternational journal of legal medicine2010
Laser capture microdissection in forensic research: a review.
Review in International journal of legal medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 81 citations in OpenAlex.
- Optical tweezers as an effective tool for spermatozoa isolation from mixed forensic samples.PloS one · 2019Trial
- Single-cell strategies for the interpretation of complex forensic DNA mixtures: isolation techniques, genotype data integration, and prospects for application.International journal of legal medicine · 2026Review
- Machine learning-assisted analysis of saliva-containing mixtures using a saliva-specific multi-CpG-microhaplotype marker system.International journal of legal medicine · 2026Article
- Evaluating novel and conventional cell-separation techniques for sexual assault investigations.Journal of forensic sciences · 2025Article
- Deciphering cellular complexity: advances and future directions in single-cell protein analysis.Frontiers in bioengineering and biotechnology · 2024Review
- Laser Microdissection-Mediated Isolation of Butterfly Wing Tissue for Spatial Transcriptomics.Methods and protocols · 2022Article
- Article
- Revisiting single cell analysis in forensic science.Scientific reports · 2021Article
- Sperm Cell Capture Based on ABH Antigen Differences to Separate Two Men in Mixed Seminal Stains.BioMed research international · 2021Article
- Separation/extraction, detection, and interpretation of DNA mixtures in forensic science (review).International journal of legal medicine · 2018Review
- Characterization of degradation and heterozygote balance by simulation of the forensic DNA analysis process.International journal of legal medicine · 2017Article
- Fluorescence- and magnetic-activated cell sorting strategies to separate spermatozoa involving plural contributors from biological mixtures for human identification.Scientific reports · 2016Article
- Isolating cells from female/male blood mixtures using florescence in situ hybridization combined with low volume PCR and its application in forensic science.International journal of legal medicine · 2015Article
- Technologies for Single-Cell Isolation.International journal of molecular sciences · 2015Review
- RNA Isolation from Cell Specific Subpopulations Using Laser-capture Microdissection Combined with Rapid Immunolabeling.Journal of visualized experiments : JoVE · 2015Article
- Y-chromosomal haplotyping of single sperm cells isolated from semen mixtures - a successful identification of three perpetrators in a multi-suspect sexual assault case.Croatian medical journal · 2014Article
- Forensic DNA research: keeping it real.International journal of legal medicine · 2012Article
- Current genetic methodologies in the identification of disaster victims and in forensic analysis.Journal of applied genetics · 2012Review
- Transcriptome analysis of single cells.Journal of visualized experiments : JoVE · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In forensic sciences, short tandem repeat (STR) analysis has become the prime tool for DNA-based identification of the donor(s) of biological stains and/or traces. Many traces, however, contain cells and, hence, DNA, from more than a single individual, giving rise to mixed genotypes and the subsequent difficulties in interpreting the results. An even more challenging situation occurs when cells of a victim are much more abundant than the cells of the perpetrator. Therefore, the forensic community seeks to improve cell-separation methods in order to generate single-donor cell populations from a mixed trace in order to facilitate DNA typing and identification. Laser capture microdissection (LCM) offers a valuable tool for precise separation of specific cells. This review summarises all possible forensic applications of LCM, gives an overview of the staining and detection options, including automated detection and retrieval of cells of interest, and reviews the DNA extraction protocols compatible with LCM of cells from forensic samples.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.