ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2010
Posterior fossa ependymomas: new radiological classification with surgical correlation.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 27 citations in OpenAlex.
- Posterior fossa ependymoma: a comprehensive review of molecular classification, management guidelines, and clinical outcomes (Part I of ependymomas across compartments).Journal of neuro-oncology · 2026Review
- Lateral-type posterior fossa ependymomas in pediatric patients: a national collaborative study.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- Primary germinoma of the medulla oblongata: illustrative case.Journal of neurosurgery. Case lessons · 2022Article
- Radiomic signatures of posterior fossa ependymoma: Molecular subgroups and risk profiles.Neuro-oncology · 2022Article
- Anatomic Neuroimaging Characteristics of Posterior Fossa Type A Ependymoma Subgroups.AJNR. American journal of neuroradiology · 2021Article
- Is H3K27me3 status really a strong prognostic indicator for pediatric posterior fossa ependymomas? A single surgeon, single center experience.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Article
- Differential diagnosis of posterior fossa tumours in children: new insights.Pediatric radiology · 2018Review
- Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas.Acta neuropathologica · 2018Article
- Quantitative imaging analysis of posterior fossa ependymoma location in children.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2016Article
- Therapeutic Impact of Cytoreductive Surgery and Irradiation of Posterior Fossa Ependymoma in the Molecular Era: A Retrospective Multicohort Analysis.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2016Article
- Posterior fossa tumors in children: developmental anatomy and diagnostic imaging.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2015Review
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe key determinant of long-term outcome in infratentorial ependymomas remains the extent of surgical resection. We describe a new radiological classification system which is validated against surgical findings and correlated with risk of post-operative residual tumour.
methodsTwenty-five consecutive patients (12 females, mean age 4.9 years, range 0.5-17 years) with infratentorial ependymomas were studied. Lesions were classified on pre-operative MRI according to the pattern of extension, brainstem displacement and involvement of the obex, as lateral-type or midfloor-type tumours. Twenty-one operative records were reviewed with respect to the microanatomical tumour origin by a paediatric neurosurgeon, blinded to MRI findings. Follow-up imaging studies were evaluated for residual tumour.
resultsThere were 15 cases of midfloor-type tumour (anterior displacement of brainstem, infiltration of obex) and 10 cases of lateral-type tumour (lateral displacement of brainstem, obex free of tumour). Extension into prepontine or cerebellopontine cisterns was more common in lateral-type tumours. Agreement between the radiological classification and tumour origin, as defined by operative records, was seen in 18 out of 20 cases. Risk of residual tumour in lateral-type tumours was more than twice that of midfloor-type tumours (80% vs. 33%, p=0.04). Risk of tumour residual was also significantly higher when vessel encasement or prepontine extension was observed.
conclusionsInfratentorial ependymomas can be pre-operatively classified as lateral-type or midfloor-type tumours. This correlates well with operative findings. Lateral-type tumours have significantly increased risk of residual tumour compared to midfloor- type tumours and this may influence intensity of imaging surveillance.
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