ArticleJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology2011
Torpor patterns, arousal rates, and temporal organization of torpor entry in wildtype and UCP1-ablated mice.
Article in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed.
- Clocks slide rather than freeze during torpor in the mouse.iScience · 2026Article
- Inhibition of daily torpor in mice requires calories, not just feeding: a potential role for GLP-1.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2026Article
- Molecular mediators of cold adaptation in mammalian cells.Communications biology · 2025Review
- The Art of Chilling Out: How Neurons Regulate Torpor.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Silencing of ultradian rhythms and metabolic depression during spontaneous daily torpor in Djungarian hamsters.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2024Article
- Induction of a torpor-like hypothermic and hypometabolic state in rodents by ultrasound.Nature metabolism · 2023Article
- Synthetic torpor triggers a regulated mechanism in the rat brain, favoring the reversibility of Tau protein hyperphosphorylation.Frontiers in physiology · 2023Article
- Pros and cons for the evidence of adaptive non-shivering thermogenesis in marsupials.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2021Review
- The relationship between fasting-induced torpor, sleep, and wakefulness in laboratory mice.Sleep · 2021Article
- Turn it off and on again: characteristics and control of torpor.Wellcome open research · 2021Review
- Control of brown adipose tissue adaptation to nutrient stress by the activin receptor ALK7.eLife · 2020Article
- Neural control of fasting-induced torpor in mice.Scientific reports · 2019Article
- Clocks and meals keep mice from being cool.The Journal of experimental biology · 2018Article
- Is Adenosine Action Common Ground for NREM Sleep, Torpor, and Other Hypometabolic States?Physiology (Bethesda, Md.) · 2018Review
- Nature's fat-burning machine: brown adipose tissue in a hibernating mammal.The Journal of experimental biology · 2018Review
- Targeting thermogenesis in brown fat and muscle to treat obesity and metabolic disease.Nature reviews. Endocrinology · 2018Review
- Pyruvate induces torpor in obese mice.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- How low can you go? An adaptive energetic framework for interpreting basal metabolic rate variation in endotherms.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2017Review
- Central activation of the AJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2017Article
- Inactivation of thermogenic UCP1 as a historical contingency in multiple placental mammal clades.Science advances · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In eutherian mammals, uncoupling protein 1 (UCP1) mediated non-shivering thermogenesis from brown adipose tissue (BAT) provides a mechanism through which arousal from torpor and hibernation is facilitated. In order to directly assess the magnitude by which the presence or absence of UCP1 affects torpor patterns, rewarming and arousal rates within one species we compared fasting induced torpor in wildtype (UCP1(+/+)) and UCP1-ablated mice (UCP(-/-)). Torpor was induced by depriving mice of food for up to 48 h and by a reduction of ambient temperature (T (a)) from 30 to 18°C at four different time points after 18, 24, 30 and 36 h of food deprivation. In most cases, torpor bouts occurred within 20 min after the switch in ambient temperature (30-18°C). Torpor bouts expressed during the light phase lasted 3-6 h while significantly longer bouts (up to 16 h) were observed when mice entered torpor during the dark phase. The degree of hypometabolism (5-22 ml h(-1)) and hypothermia (19.5-26.7°C) was comparable in wildtype and UCP1-ablated mice, and both genotypes were able to regain normothermia. In contrast to wildtype mice, UCP1-ablated mice did not display multiple torpor bouts per day and their peak rewarming rates from torpor were reduced by 50% (UCP1(+/+): 0.24 ± 0.08°C min(-1); UCP1(-/-): 0.12 ± 0.04°C min(-1)). UCP1-ablated mice therefore took significantly longer to rewarm from 25 to 32°C (39 vs. 70 min) and required 60% more energy for this process. Our results demonstrate the energetic benefit of functional BAT for rapid arousal from torpor. They also suggest that torpor entry and maintenance may be dependent on endogenous rhythms.
Indexed as
Identifiers
20680295What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.