ArticleJournal of neurogastroenterology and motility2010
The role of weakly acidic reflux in proton pump inhibitor failure, has dust settled?
Article in Journal of neurogastroenterology and motility, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 42 citations in OpenAlex.
- Randomised clinical trial: mucosal protection combined with acid suppression in the treatment of non-erosive reflux disease - efficacy of Esoxx, a hyaluronic acid-chondroitin sulphate based bioadhesive formulation.Alimentary pharmacology & therapeutics · 2017Trial
- Article
- Dynorphin participates in interaction between depression and non-erosive reflux disease.Esophagus : official journal of the Japan Esophageal Society · 2023Article
- [Treatment of Acid-related Diseases Using Potassium-competitive Acid Blockers].The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2022Review
- Barrett's Esophagus and Intestinal Metaplasia.Frontiers in oncology · 2021Review
- Current therapies for gastro-oesophageal reflux in the setting of chronic lung disease: state of the art review.ERJ open research · 2020Review
- Symptomatic response to GERDOFF® in patients with gastro-esophageal reflux disease and poor response to alginates: an exploratory, post-market, open-label study.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2020Article
- Effects of Transcutaneous Electrical Acustimulation on Refractory Gastroesophageal Reflux Disease.Evidence-based complementary and alternative medicine : eCAM · 2016Article
- Refractory chronic cough due to gastroesophageal reflux: Definition, mechanism and management.World journal of methodology · 2015Review
- Acid and non-acid reflux in patients refractory to proton pump inhibitor therapy: is gastroparesis a factor?World journal of gastroenterology · 2013Article
- Therapeutic efficacy of baclofen in refractory gastroesophageal reflux-induced chronic cough.World journal of gastroenterology · 2013Article
- Effect of proton pump inhibition on acid, weakly acid and weakly alkaline gastro-esophageal reflux in children.World journal of pediatrics : WJP · 2013Article
- Successful resolution of refractory chronic cough induced by gastroesophageal reflux with treatment of baclofen.Cough (London, England) · 2012Article
- Nocturnal gastroesophageal reflux revisited by impedance-pH monitoring.Journal of neurogastroenterology and motility · 2011Article
- Current and emerging therapies for the management of functional gastrointestinal disorders.Therapeutic advances in chronic disease · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients that do not respond satisfactorily to standard proton pump inhibitor (PPI) treatment have become the most common presentation of gastro-esophageal reflux disease (GERD) in third referral gastrointestinal practices. The causes of refractory GERD include lack of compliance with treatment, residual acid reflux and weakly acidic reflux, esophageal hypersensitivity and persistent symptoms not associated with reflux. A role for weakly acidic reflux in symptom generation has been proposed since the availability of impedance-pH monitoring. The possible mechanisms by which persistent weakly acidic reflux might contribute to persistent symptoms in patients under PPI treatment may include esophageal distension by increased reflux volume, persistent impaired mucosal integrity (ie, dilation of intercellular spaces) and/or esophageal hypersensitivity to weakly acidic reflux events. To establish a definite role of weakly acidic reflux in refractory GERD, outcome studies targeting this type of reflux are still lacking. Treatment strategies to reduce the number or effect of weakly acidic reflux could involve drugs that decrease transient lower esophageal sphincter relaxations (ie, baclofen or similar), improve oesophageal mucosa resistance or visceral pain modulators. Finally, anti-reflux surgery can be considered, only if a clear symptom-weakly acidic reflux association was demonstrated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.