ArticleJournal of immunology (Baltimore, Md. : 1950)2010
Dendritic cell modification of neutrophil responses to infection after burn injury.
Article in Journal of immunology (Baltimore, Md. : 1950), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
24 citing papers in PubMed, 34 citations in OpenAlex.
- Immunoadjuvant therapy in the regulation of cell death in sepsis: recent advances and future directions.Frontiers in immunology · 2024Review
- Murine scald models characterize the role of neutrophils and neutrophil extracellular traps in severe burns.Frontiers in immunology · 2023Article
- A Murine Model of Full-Thickness Scald Burn Injury with Subsequent Wound and Systemic Bacterial Infection.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Pathological alteration and therapeutic implications of sepsis-induced immune cell apoptosis.Cell death & disease · 2019Review
- The Cutaneous Inflammatory Response to Thermal Burn Injury in a Murine Model.International journal of molecular sciences · 2019Article
- Rictor deficiency in dendritic cells exacerbates acute kidney injury.Kidney international · 2018Article
- Toll-like receptors in immunity and inflammatory diseases: Past, present, and future.International immunopharmacology · 2018Review
- Frontline Science: Anti-PD-L1 protects against infection with common bacterial pathogens after burn injury.Journal of leukocyte biology · 2018Article
- Type I interferons drive inflammasome-independent emergency monocytopoiesis during endotoxemia.Scientific reports · 2017Article
- Fms-like tyrosine kinase-3 ligand increases resistance to burn wound infection through effects on plasmacytoid dendritic cells.BMC immunology · 2017Article
- Flt3 Ligand Treatment Attenuates T Cell Dysfunction and Improves Survival in a Murine Model of Burn Wound Sepsis.Shock (Augusta, Ga.) · 2017Article
- Timeline of health care-associated infections and pathogens after burn injuries.American journal of infection control · 2016Article
- Role of cellular events in the pathophysiology of sepsis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2016Review
- Immunotherapy: A promising approach to reverse sepsis-induced immunosuppression.Pharmacological research · 2016Review
- Role of G-CSF in monophosphoryl lipid A-mediated augmentation of neutrophil functions after burn injury.Journal of leukocyte biology · 2016Article
- Differential acute and chronic effects of burn trauma on murine skeletal muscle bioenergetics.Burns : journal of the International Society for Burn Injuries · 2016Article
- IL-15 Superagonist Expands mCD8+ T, NK and NKT Cells after Burn Injury but Fails to Improve Outcome during Burn Wound Infection.PloS one · 2016Article
- Validation of a Radiography-Based Quantification Designed to Longitudinally Monitor Soft Tissue Calcification in Skeletal Muscle.PloS one · 2016Article
- Severe Burn Injury Induces Thermogenically Functional Mitochondria in Murine White Adipose Tissue.Shock (Augusta, Ga.) · 2015Article
- Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy.Nature reviews. Immunology · 2013Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
Abstract
Burn patients are highly susceptible to infections due to increased exposure through wounds and impairments in a number of immune functions. Dendritic cells (DCs) are important in activation of numerous immune responses that are essential for the clearance of infections. We have found that prophylactic treatment of burn-injured mice with the DC growth factor FLT3 ligand (FL) significantly increases resistance to burn wound infections in a DC-dependent manner that is correlated closely with enhanced bacterial clearance. However, as DCs are not typically microbicidal, the mechanisms by which DC modulation enhances bacterial clearance are not known. Due to the rapid response of neutrophils to cutaneous wounds, and the reported interactions between DCs and neutrophils, we investigated the role of neutrophils in FL-mediated resistance to burn wound infection. This was examined both in vivo and in vitro through neutrophil depletion, supplementation of neutrophils, and assessment of neutrophil chemotaxis following FL treatment. To test the involvement of DCs, CD11c-diphtheria toxin receptor transgenic mice were used to deplete DCs during FL treatment. Studies revealed that neutrophils do play a critical role in FL-mediated resistance to a burn wound infection. Additionally, treatment with FL after a burn injury enhances neutrophil-mediated control of bacterial spread, neutrophil migratory capacity, and myeloperoxidase production in a DC-dependent manner. The results of this study provide new insight into immunological mechanisms that can offer protection against infection after burn injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.