ArticleAntimicrobial agents and chemotherapy2010
Increased temperature enhances the antimicrobial effects of daptomycin, vancomycin, tigecycline, fosfomycin, and cefamandole on staphylococcal biofilms.
Article in Antimicrobial agents and chemotherapy, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Systemic and local effects of vancomycin-combined thermal exposure on Staphylococcus aureus infected rat femurs: a comparative study of hyperthermia and thermal ablation.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Staphylococcal proliferation on skin models to investigate novel anti-infective treatments against dysbiosis.Bioengineering & translational medicine · 2026Article
- Characterizing Environmental Background Microflora and Assessing Their Influence onFoods (Basel, Switzerland) · 2025Article
- Gene knockout studies of Dps protein reveals a novel role for DNA-binding protein in maintaining outer membrane permeability.World journal of microbiology & biotechnology · 2025Article
- Preservatives for postmortem brain tissue in biomechanical testing: A pilot study.Journal of anatomy · 2024Article
- Antibiotic Augmentation of Thermal Eradication ofPathogens (Basel, Switzerland) · 2024Article
- Hyperthermia PreventsMicrobiology spectrum · 2023Article
- Therapeutic hyperthermia for the treatment of infection-a narrative review.Frontiers in physiology · 2023Review
- Temperature control in sepsis.Frontiers in medicine · 2023Review
- Effectiveness of mechanical cleaning, antibiotics, and induction heating on eradication ofBone & joint research · 2022Article
- Warming up for a better fever: a randomized pilot study in pediatric oncology.Pilot and feasibility studies · 2022Article
- Aptamer-Targeted Drug Delivery forFrontiers in cellular and infection microbiology · 2022Article
- Thermal Shock and Ciprofloxacin Act Orthogonally onAntibiotics (Basel, Switzerland) · 2021Article
- Adjuvant antibiotic-loaded bone cement: Concerns with current use and research to make it work.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Article
- The FeverApp registry - ecological momentary assessment (EMA) of fever management in families regarding conformity to up-to-date recommendations.BMC medical informatics and decision making · 2020Article
- Induction heating for eradicatingBone & joint research · 2020Article
- Sonobactericide: An Emerging Treatment Strategy for Bacterial Infections.Ultrasound in medicine & biology · 2020Review
- Antimicrobial Susceptibility Testing of Antimicrobial Peptides to Better Predict Efficacy.Frontiers in cellular and infection microbiology · 2020Review
- Effects of biotic and abiotic factors on biofilm growth dynamics and their heterogeneous response to antibiotic challenge.Journal of biosciences · 2020Review
- Bacteria as biological control agents of freshwater cyanobacteria: is it feasible beyond the laboratory?Applied microbiology and biotechnology · 2018Review
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Implant-related infections are serious complications of trauma and orthopedic surgery and are most difficult to treat. The bacterial biofilms of 34 clinical Staphylococcus sp. isolates (Staphylococcus aureus, n = 14; coagulase-negative staphylococci, n = 19) were incubated with daptomycin (DAP; 5, 25, or 100 mg/liter), vancomycin (VAN; 5, 25, or 100 mg/liter), tigecycline (TGC; 1, 5, or 25 mg/liter), fosfomycin (FOM; 100, 250, or 1,000 mg/liter), and cefamandole (FAM; 50, 100, or 500 mg/liter) for 24 h at three different ambient temperatures: 35°C, 40°C, and 45°C. To quantify the reduction of the biomass, the optical density ratio (ODr) of stained biofilms and the number of growing bacteria were determined. Increasing the temperature to 45°C or to 40°C during incubation with FAM, FOM, TGC, VAN, or DAP led to a significant but differential reduction of the thickness of the staphylococcal biofilms compared to that at 35°C (P < 0.05). Growth reduction was enhanced for DAP at 100 mg/liter at 35°C, 40°C, and 45°C (log count reductions, 4, 3.6, and 3.3, respectively; P < 0.05). A growth reduction by 2 log counts was detected for FAM at a concentration of 500 mg/liter at 40°C and 45°C (P = 0.01). FOM at 1,000 mg/liter reduced the bacterial growth by 1.2 log counts (not significant). The antibacterial activity of antimicrobial agents is significantly but differentially enhanced by increasing the ambient temperature and using high concentrations. Adjuvant hyperthermia may be of value in the treatment of biofilm-associated implant-related infections.
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