ArticleMolecular and cellular biology2010
Cellular prion protein promotes regeneration of adult muscle tissue.
Article in Molecular and cellular biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 56 citations in OpenAlex.
- PrPJournal of cachexia, sarcopenia and muscle · 2025Article
- Roles of prion proteins in mammalian development.Animal cells and systems · 2024Review
- Excess PrPNature communications · 2023Article
- The Multifaceted Functions of Prion Protein (PrPCancers · 2023Review
- Detailing the ultrastructure's increase of prion protein in pancreatic adenocarcinoma.World journal of gastroenterology · 2021Article
- Cellular prion protein dysfunction in a prototypical inherited metabolic myopathy.Cellular and molecular life sciences : CMLS · 2021Article
- Article
- Microglia in Prion Diseases: Angels or Demons?International journal of molecular sciences · 2020Review
- The cellular prion protein promotes olfactory sensory neuron survival and axon targeting during adult neurogenesis.Developmental biology · 2018Article
- Cellular prion protein (PrPOncogene · 2017Article
- Role of hypoxia‑mediated cellular prion protein functional change in stem cells and potential application in angiogenesis (Review).Molecular medicine reports · 2017Article
- Protective role of cellular prion protein against TNFα-mediated inflammation through TACE α-secretase.Scientific reports · 2017Article
- Cellular prion protein controls stem cell-like properties of human glioblastoma tumor-initiating cells.Oncotarget · 2016Article
- Cellular Prion Protein Promotes Neuronal Differentiation of Adipose-Derived Stem Cells by Upregulating miRNA-124.Journal of molecular neuroscience : MN · 2016Article
- Activation of zebrafish Src family kinases by the prion protein is an amyloid-β-sensitive signal that prevents the endocytosis and degradation of E-cadherin/β-catenin complexes in vivo.Molecular neurodegeneration · 2016Article
- Prion protein- and cardiac troponin T-marked interstitial cells from the adult myocardium spontaneously develop into beating cardiomyocytes.Scientific reports · 2014Article
- Foodborne transmission of bovine spongiform encephalopathy to non-human primates results in preclinical rapid-onset obesity.PloS one · 2014Article
- Article
- To develop with or without the prion protein.Frontiers in cell and developmental biology · 2014Review
- PrP(C) from stem cells to cancer.Frontiers in cell and developmental biology · 2014Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
It is now well established that the conversion of the cellular prion protein, PrP(C), into its anomalous conformer, PrP(Sc), is central to the onset of prion disease. However, both the mechanism of prion-related neurodegeneration and the physiologic role of PrP(C) are still unknown. The use of animal and cell models has suggested a number of putative functions for the protein, including cell signaling, adhesion, proliferation, and differentiation. Given that skeletal muscles express significant amounts of PrP(C) and have been related to PrP(C) pathophysiology, in the present study, we used skeletal muscles to analyze whether the protein plays a role in adult morphogenesis. We employed an in vivo paradigm that allowed us to compare the regeneration of acutely damaged hind-limb tibialis anterior muscles of mice expressing, or not expressing, PrP(C). Using morphometric and biochemical parameters, we provide compelling evidence that the absence of PrP(C) significantly slows the regeneration process compared to wild-type muscles by attenuating the stress-activated p38 pathway, and the consequent exit from the cell cycle, of myogenic precursor cells. Demonstrating the specificity of this finding, restoring PrP(C) expression completely rescued the muscle phenotype evidenced in the absence of PrP(C).
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.