ArticleInfection and immunity2010
Impaired immune tolerance to Porphyromonas gingivalis lipopolysaccharide promotes neutrophil migration and decreased apoptosis.
Article in Infection and immunity, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 69 citations in OpenAlex.
- Repurposing Metformin for periodontal disease management as a form of oral-systemic preventive medicine.Journal of translational medicine · 2023Trial
- Trial
- Functions of Macrophages in Periodontal Disease Progression and Gingival Tissue Homeostasis.Advances in experimental medicine and biology · 2026Review
- Article
- Microbial dysbiosis and immune dysregulation in periodontitis and peri-implantitis.Frontiers in cellular and infection microbiology · 2025Review
- AmSystems · 2024Article
- Arginine-specific gingipains (RgpA/RgpB) knockdown modulates neutrophil machinery.Journal of oral microbiology · 2024Article
- Article
- Biomarkers common for inflammatory periodontal disease and depression: A systematic review.Brain, behavior, & immunity - health · 2022Review
- Does Oral Endotoxin Contribute to Systemic Inflammation?Frontiers in oral health · 2022Review
- Pyroptosis-Mediated Periodontal Disease.International journal of molecular sciences · 2021Review
- Is the oral microbiome a source to enhance mucosal immunity against infectious diseases?NPJ vaccines · 2021Review
- Effects of Endotoxin Tolerance Induced by Porphyromonas gingivalis Lipopolysaccharide on Inflammatory Responses in Neutrophils.Inflammation · 2020Article
- Porphyromonas gingivalis adopts intricate and unique molecular mechanisms to survive and persist within the host: a critical update.Journal of oral microbiology · 2020Review
- Compromised inflammatory cytokine response to P. gingivalis LPS by fibroblasts from inflamed human gingiva.Clinical oral investigations · 2018Article
- Resolution of inflammation in periodontitis: a review.International journal of clinical and experimental pathology · 2018Review
- Increased visfatin expression is associated with nuclear factor-kappa B and phosphatidylinositol 3-kinase in periodontal inflammation.Clinical oral investigations · 2017Article
- Manipulation of Neutrophils byFrontiers in cellular and infection microbiology · 2017Review
- [Developments of neutrophil function and the relationship between neutrophils dysfunction and periodontitis].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2016Article
- Major neutrophil functions subverted by Porphyromonas gingivalis.Journal of oral microbiology · 2016Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Periodontitis, a chronic inflammatory disease of the tissues supporting the teeth, is characterized by an exaggerated host immune and inflammatory response to periopathogenic bacteria. Toll-like receptor activation, cytokine network induction, and accumulation of neutrophils at the site of inflammation are important in the host defense against infection. At the same time, induction of immune tolerance and the clearance of neutrophils from the site of infection are essential in the control of the immune response, resolution of inflammation, and prevention of tissue destruction. Using a human monocytic cell line, we demonstrate that Porphyromonas gingivalis lipopolysaccharide (LPS), which is a major etiological factor in periodontal disease, induces only partial immune tolerance, with continued high production of interleukin-8 (IL-8) but diminished secretion of tumor necrosis factor alpha (TNF-α) after repeated challenge. This cytokine response has functional consequences for other immune cells involved in the response to infection. Primary human neutrophils incubated with P. gingivalis LPS-treated naïve monocyte supernatant displayed a high migration index and increased apoptosis. In contrast, neutrophils treated with P. gingivalis LPS-tolerized monocyte supernatant showed a high migration index but significantly decreased apoptosis. Overall, these findings suggest that induction of an imbalanced immune tolerance in monocytes by P. gingivalis LPS, which favors continued secretion of IL-8 but decreased TNF-α production, may be associated with enhanced migration of neutrophils to the site of infection but also with decreased apoptosis and may play a role in the chronic inflammatory state seen in periodontal disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.