ArticleEuropean journal of endocrinology2010
Adiposity and insulin resistance correlate with telomere length in middle-aged Arabs: the influence of circulating adiponectin.
Article in European journal of endocrinology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
48 citing papers in PubMed, 88 citations in OpenAlex.
- Telomere shortening associates with elevated insulin and nuchal fat accumulation.Scientific reports · 2020Trial
- Trial
- Structured lifestyle modification and biological aging: effects on PhenoAge, sclerostin, and GDF-15 in arab adults with prediabetes.Frontiers in aging · 2026Article
- Examining the relationship between cardiometabolic risk factors and telomere length in women: a systematic review.Innovation in aging · 2025Review
- Study of association of leptin with leukocyte telomere length in a Chinese rural population.Lipids in health and disease · 2024Article
- Insulin and aging - a disappointing relationship.Frontiers in endocrinology · 2023Review
- Telomere Length Is Correlated with Resting Metabolic Rate and Aerobic Capacity in Women: A Cross-Sectional Study.International journal of molecular sciences · 2022Article
- The Emerging Role of the Aging Process and Exercise Training on the Crosstalk between Gut Microbiota and Telomere Length.International journal of environmental research and public health · 2022Review
- Endotoxemia, vitamin D and premature biological ageing in Arab adults with different metabolic states.Saudi journal of biological sciences · 2022Article
- Telomere length and telomere repeat-binding protein in children with sickle cell disease.Pediatric research · 2022Article
- Neck-to-height ratio is positively associated with diabetic kidney disease in Chinese patients with type 2 diabetes mellitus.Frontiers in endocrinology · 2022Article
- Triglyceride-Glucose Index Correlate With Telomere Length in Healthy Adults From the National Health and Nutrition Examination Survey.Frontiers in endocrinology · 2022Article
- Insulin Resistance and Biological Aging: The Role of Body Mass, Waist Circumference, and Inflammation.BioMed research international · 2022Article
- Gut-Derived Endotoxin and Telomere Length Attrition in Adults with and without Type 2 Diabetes.Biomolecules · 2021Article
- Telomere Length and Oxidative Stress and Its Relation with Metabolic Syndrome Components in the Aging.Biology · 2021Review
- Association Between Weight Change and Leukocyte Telomere Length in U.S. Adults.Frontiers in endocrinology · 2021Article
- Serum anti-inflammatory and inflammatory markers have no causal impact on telomere length: a Mendelian randomization study.Archives of medical science : AMS · 2021Article
- Mendelian randomization implies no direct causal association between leukocyte telomere length and amyotrophic lateral sclerosis.Scientific reports · 2020Article
- Functional interaction between plasma phospholipid fatty acids and insulin resistance in leucocyte telomere length maintenance.Lipids in health and disease · 2020Article
- Telomere Length: A Potential Biomarker for the Risk and Prognosis of Stroke.Frontiers in neurology · 2019Review
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveStudies in obesity have implicated adipocytokines in the development of insulin resistance, which in turn may lead to accelerated aging. In this study, we determined associations of chromosomal telomere length (TL) to markers of obesity and insulin resistance in middle-aged adult male and female Arabs with and without diabetes mellitus type 2 (DMT2). DESIGN AND
methodsOne hundred and ninety-three non-diabetic and DMT2 subjects without complications (97 males and 96 females) participated in this cross-sectional study. Clinical data, as well as fasting blood samples, were collected. Serum glucose and lipid profile were determined using routine laboratory methods. Serum insulin, leptin, adiponectin, resistin, tumor necrosis factor-α, and PAI-1 were quantified using customized multiplex assay kits. High sensitive C-reactive protein (hsCRP) and angiotensin II (ANG II) were measured using ELISAs. Circulating leukocyte TL was examined by quantitative real-time PCR.
resultsCirculating chromosomal leukocyte TL had significant inverse associations with body mass index (BMI), systolic blood pressure, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), low-density lipoprotein (LDL)- and total cholesterol, ANG II and hsCRP levels. Adiponectin, BMI, systolic blood pressure, and LDL cholesterol predicted 47% of the variance in TL (P<0.0001). HOMA-IR was the most significant predictor for TL in males, explaining 35% of the variance (P=0.01). In females, adiponectin accounted for 28% of the variance in TL (P=0.01).
conclusionObesity and insulin resistance are associated with chromosomal TL among adult Arabs. Evidence of causal relations needs further investigation. The positive association of adiponectin to TL has clinical implications as to the possible protective effects of this hormone from accelerated aging.
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Registered trials
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