ArticleThe Journal of physiology2010
Is the efficiency of mammalian (mouse) skeletal muscle temperature dependent?
Article in The Journal of physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Distinct distributions of myosin motor conformations during contraction of slow and fast skeletal muscle.The Journal of physiology · 2026Article
- Body Temperature Regulation in the Rat by Muscle Tone.Acta physiologica (Oxford, England) · 2026Article
- A combined experimental and computational analysis of mantATP turnover in skinned muscle fibers.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Using physiologically based models to predict in vivo skeletal muscle energetics.The Journal of experimental biology · 2025Article
- Male and female syringeal muscles exhibit superfast shortening velocities in zebra finches.The Journal of experimental biology · 2024Article
- Force and kinetics of fast and slow muscle myosin determined with a synthetic sarcomere-like nanomachine.Communications biology · 2024Article
- Impairments in muscle shape changes affect metabolic demands duringProceedings. Biological sciences · 2023Article
- Matching Mechanics and Energetics of Muscle Contraction Suggests Unconventional Chemomechanical Coupling during the Actin-Myosin Interaction.International journal of molecular sciences · 2023Article
- A century of exercise physiology: key concepts in muscle energetics.European journal of applied physiology · 2023Review
- The legacy of A. V. Hill's Nobel Prize winning work on muscle energetics.The Journal of physiology · 2022Article
- Ryanodine receptor leak triggers fiber CaScience advances · 2021Article
- Muscle-specific economy of force generation and efficiency of work production during human running.eLife · 2021Article
- Myosin-based regulation of twitch and tetanic contractions in mammalian skeletal muscle.eLife · 2021Article
- Components of activation heat in skeletal muscle.Journal of muscle research and cell motility · 2021Article
- Lifespan Analysis of DystrophicFrontiers in physiology · 2021Article
- Paxilline Prevents the Onset of Myotonic Stiffness in Pharmacologically Induced Myotonia: A Preclinical Investigation.Frontiers in physiology · 2020Article
- Energy Expenditure of Dynamic Submaximal Human Plantarflexion Movements: Model Prediction and Validation byFrontiers in bioengineering and biotechnology · 2020Article
- Bioenergetic basis for the increased fatigability with ageing.The Journal of physiology · 2019Article
- Isoproterenol enhances force production in mouse glycolytic and oxidative muscle via separate mechanisms.Pflugers Archiv : European journal of physiology · 2019Article
- Metabolic Cost of Activation and Mechanical Efficiency of Mouse Soleus Muscle Fiber Bundles During Repetitive Concentric and Eccentric Contractions.Frontiers in physiology · 2019Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myosin crossbridges in muscle convert chemical energy into mechanical energy. Reported values for crossbridge efficiency in human muscles are high compared to values measured in vitro using muscles of other mammalian species. Most in vitro muscle experiments have been performed at temperatures lower than mammalian physiological temperature, raising the possibility that human efficiency values are higher than those of isolated preparations because efficiency is temperature dependent. The aim of this study was to determine the effect of temperature on the efficiency of isolated mammalian (mouse) muscle. Measurements were made of the power output and heat production of bundles of muscle fibres from the fast-twitch extensor digitorum longus (EDL) and slow-twitch soleus muscles during isovelocity shortening. Mechanical efficiency was defined as the ratio of power output to rate of enthalpy output, where rate of enthalpy output was the sum of the power output and rate of heat output. Experiments were performed at 20, 25 and 30◦C. Maximum efficiency of EDL muscles was independent of temperature; the highest value was 0.31}0.01 (n =5) at 30◦C. Maximum efficiency of soleus preparations was slightly but significantly higher at 25 and 30◦C than at 20◦C; the maximum mean value was 0.48±0.02 (n =7) at 25◦C. It was concluded that maximum mechanical efficiency of isolated mouse muscle was little affected by temperature between 20 and 30◦C and that it is unlikely that differences in temperature account for the relatively high efficiency of human muscle in vivo compared to isolated mammalian muscles.
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