Evidence map›Paper›PMID 20679337›Full record

ReviewCold Spring Harbor perspectives in biology2010

Zebrafish models of p53 functions.

Narie Y Storer, Leonard I Zon

Abstract readReview
In one paragraph

Review in Cold Spring Harbor perspectives in biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. UVB Irradiation Induced Cell Damage and Early Onset ofAnimals : an open access journal from MDPI · 2020
    Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. p53 induction and cell viability modulation by genotoxic individual chemicals and mixtures.Environmental science and pollution research international · 2018
    Article
  16. Article
  17. Article
  18. p53 Isoforms: Key Regulators of the Cell Fate Decision.Cold Spring Harbor perspectives in medicine · 2016
    Review
  19. A fresh look at zebrafish from the perspective of cancer research.Journal of experimental & clinical cancer research : CR · 2015
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Narie Y StorerStem Cell Program and Division of Hematology/Oncology, Children's Hospital Boston and Dana-Farber Cancer Institute, Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
Leonard I Zon

Funding

Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0M
Molecular, Cellular, & Developmental Dynamics PhD ProgramT32GM007226 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI VAN VACTOR, DAVID L. · 1985 to 2021
$14.4M
Cancer Biology in the ZebrafishR01CA103846 · NCI · CHILDREN'S HOSPITAL BOSTON · PI ZON, LEONARD IRA · 2003 to 2022
$7.5M
Howard Hughes Medical InstituteNCI NIH HHS 5R01 CA103846-07NCI NIH HHS R01 CA103846NIGMS NIH HHS GM07226NIGMS NIH HHS T32 GM007226NIGMS NIH HHS T32 GM007753
6 · The paper itself

Abstract

Zebrafish models have significantly contributed to our understanding of vertebrate development and, more recently, human disease. The growing number of genetic tools available in zebrafish research has resulted in the identification of many genes involved in developmental and disease processes. In particular, studies in the zebrafish have clarified roles of the p53 tumor suppressor in the formation of specific tumor types, as well as roles of p53 family members during embryonic development. The zebrafish has also been instrumental in identifying novel mechanisms of p53 regulation and highlighting the importance of these mechanisms in vivo. This article will summarize how zebrafish models have been used to reveal numerous, important aspects of p53 function.

Indexed as

Gene Expression RegulationGene Expression Regulation, NeoplasticGenes, p53AnimalsApoptosisCell CycleDNA-Binding ProteinsHumansModels, AnimalModels, GeneticMolecular BiologyNuclear ProteinsPhosphoproteinsRibosomal ProteinsTrans-ActivatorsTumor Protein p73DNA-Binding ProteinsNuclear ProteinsPhosphoproteinsRibosomal ProteinsTp63 protein, zebrafishTrans-ActivatorsTumor Protein p73Tumor Suppressor Protein p53Tumor Suppressor ProteinsZebrafish Proteins

Identifiers

PMID20679337
PMCPMC2908773

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.