ArticleProceedings of the National Academy of Sciences of the United States of America2010
Estrogen-dependent gallbladder carcinogenesis in LXRbeta-/- female mice.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 3 of them syntheses that pooled it.
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Who cites it
39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Effect of diabetes mellitus on survival in patients with gallbladder Cancer: a systematic review and meta-analysis.BMC cancer · 2020Pooled it
- Body Mass Index Can Increase the Risk of Gallbladder Cancer: A Meta-Analysis of 14 Cohort Studies.Medical science monitor basic research · 2016Pooled it
- Body Mass Index and Risk of Gallbladder Cancer: Systematic Review and Meta-Analysis of Observational Studies.Nutrients · 2015Pooled it
- Pancreaticobiliary Maljunction Independently Predicts Early Recurrence after Surgical Resection for Gallbladder Carcinoma without Hepaticojejunostomy: A Propensity-Weighted Cohort Study.Annals of surgical oncology · 2026Article
- Disparities in Gallbladder Cancer: Epidemiology, Molecular Mechanisms, and Clinical Implications.Molecular biology reports · 2026Review
- Sex-specific associations of SHBG, testosterone, and obesity with cholecystectomy risk: a population-based cohort study.Biology of sex differences · 2026Article
- Preoperative clinical and contrasted-enhanced CT features to predict perineural invasion in gallbladder carcinoma: focus on clinical T3-4 stage.Abdominal radiology (New York) · 2025Article
- Global trends in gallbladder cancer survival: A 30-year analysis of cancer registry data.Heliyon · 2025Review
- Expression Pattern of Estrogen Receptor Alpha and Progesterone Receptor in Gallbladder Carcinoma and Their Association with Clinicopathological Parameters and Overall Survival.Journal of gastrointestinal cancer · 2024Article
- Article
- Association with menopausal hormone therapy and asymptomatic gallstones in US women in the third National Health and Nutrition Examination Study.Scientific reports · 2024Article
- Bile Acids-A Peek Into Their History and Signaling.Endocrinology · 2022Article
- Exosomal MicroRNA signature acts as an efficient biomarker for non-invasive diagnosis of gallbladder carcinoma.iScience · 2022Article
- Establishment and characterization of an immortalized epithelial cell line from human gallbladder.Frontiers in oncology · 2022Article
- Liver X receptorAmerican journal of physiology. Gastrointestinal and liver physiology · 2021Article
- Cell of origin in biliary tract cancers and clinical implications.JHEP reports : innovation in hepatology · 2021Review
- Evaluation of the chemopreventive potentials of ezetimibe and aspirin in a novel mouse model of gallbladder preneoplasia.Molecular oncology · 2020Article
- Article
- Characteristics of a novel cell line ZJU-0430 established from human gallbladder carcinoma.Cancer cell international · 2019Article
- Efatutazone and T0901317 exert synergistically therapeutic effects in acquired gefitinib-resistant lung adenocarcinoma cells.Cancer medicine · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gallbladder cancer is a highly aggressive disease with poor prognosis that is two to six times more frequent in women than men. The development of gallbladder cancer occurs over a long time (more than 15 y) and evolves from chronic inflammation to dysplasia/metaplasia, carcinoma in situ, and invasive carcinoma. In the present study we found that, in female mice in which the oxysterol receptor liver X receptor-beta (LXRbeta) has been inactivated, preneoplastic lesions of the gallbladder developed and evolved to cancer in old animals. LXRbeta is a nuclear receptor involved in the control of lipid homeostasis, glucose metabolism, inflammation, proliferation, and CNS development. LXRbeta(-/-) female gallbladders were severely inflamed, with regions of dysplasia and high cell density, hyperchromasia, metaplasia, and adenomas. No abnormalities were evident in male mice, nor in LXRalpha(-/-) or LXRalpha(-/-)beta(-/-) animals of either sex. Interestingly, the elimination of estrogens with ovariectomy prevented development of preneoplastic lesions in LXRbeta(-/-) mice. The etiopathological mechanism seems to involve TGF-beta signaling, as the precancerous lesions were characterized by strong nuclear reactivity of phospho-SMAD-2 and SMAD-4 and loss of E-cadherin expression. Upon ovariectomy, E-cadherin was reexpressed on the cell membranes and immunoreactivity of pSMAD-2 in the nuclei was reduced. These findings suggest that LXRbeta in a complex interplay with estrogens and TGF-beta could play a crucial role in the malignant transformation of the gallbladder epithelium.
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