Evidence map›Paper›PMID 20679216›Full record

Trial reportProceedings of the National Academy of Sciences of the United States of America2010

Neural sensitivity to social rejection is associated with inflammatory responses to social stress.

George M Slavich, Baldwin M Way, Naomi I Eisenberger, Shelley E Taylor

4 registry-linked trialsOpen access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 187 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
187citing papers in PubMed, 5 pooled it
6.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02972554 phase4completednot on this mapstarted 2016, after this paper: background citation

Beta-Blockers and Inflammatory Responses to Acute Psychosocial Stress

TypeinterventionalSponsorUniversity of North Carolina, Chapel HillRan2016 to 2017Enrolled92ConditionsStress, Psychological, Inflammation, Cortisol, Sympathetic Nervous SystemArmsPropanolol hydrochloride, Placebo
NCT05654441 phase4completednot on this mapstarted 2022, after this paper: background citation

Low-grade Inflammatory Challenge and Social Behavior

TypeinterventionalSponsorUniversity of North Carolina, Chapel HillRan2022 to 2023Enrolled104ConditionsPsychology, Social, Inflammation, Defeat, Social, Interaction, SocialArmsInfluenza vaccine, Placebo
NCT06063174 nacompletednot on this mapstarted 2023, after this paper: background citation

Identifying Social, Molecular, & Immunological Processes for Mitigating Toxic Stress & Enhancing Personalized Resilience

TypeinterventionalSponsorUniversity of California, Los AngelesRan2023 to 2024Enrolled712ConditionsStress, Stress, Psychological, Stress, Physiological, Stress, EmotionalArmsEducation Program, Think Well Program, Be Well Program, Eat Well Program, Sleep Well Program
NCT06263452 phase4recruitingnot on this mapstarted 2024, after this paper: background citation

Beta-Blocker Influences on Inflammatory and Neural Responses to Stress

TypeinterventionalSponsorUniversity of North Carolina, Chapel HillRan2024 to 2026Enrolled120ConditionsCardiovascular DiseaseArmsPropranolol, Placebo
3 · Its place in the literature

Who cites it

187 citing papers in PubMed, 5 syntheses or guidelines pooled it, 407 citations in OpenAlex.

  1. Pooled it
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  4. A meta-analysis of the anterior cingulate contribution to social pain.Social cognitive and affective neuroscience · 2015
    Pooled it
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  8. Alleviating Social Pain: A Double-Blind, Randomized, Placebo-Controlled Trial of Forgiveness and Acetaminophen.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2019
    Trial
  9. Brain connectivity dynamics during social interaction reflect social network structure.Proceedings of the National Academy of Sciences of the United States of America · 2017
    Trial
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127 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

George M SlavichDepartment of Psychology, Cousins Center for Psychoneuroimmunology, University of California, Los Angeles, CA 90095, USA.
Baldwin M Way
Naomi I Eisenberger
Shelley E Taylor
University of California, Los Angeles · USInstitute of Neuroimmunology of the Slovak Academy of Sciences · SK

Funding

Post-Graduate Training Program in Psychoneuroimmunology and Mental HealthT32MH019925 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI IRWIN, MICHAEL R · 1997 to 2012
$1.7M
SELF-REGULATORY ASPECTS OF POSITIVE ILLUSIONSR01MH056880 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TAYLOR, SHELLEY E · 1998 to 2005
$981k
Psychological and Biological Antecedents of Health Behavior DecisionsR01AG030309 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TAYLOR, SHELLEY E · 2006 to 2008
$782k
NIA NIH HHS AG030309NIA NIH HHS R01 AG030309NIMH NIH HHS MH56880NIMH NIH HHS R01 MH056880NIMH NIH HHS T32 MH019925NIMH NIH HHS T32MH019925
6 · The paper itself

Abstract

Although stress-induced increases in inflammation have been implicated in several major disorders, including cardiovascular disease and depression, the neurocognitive pathways that underlie inflammatory responses to stress remain largely unknown. To examine these processes, we recruited 124 healthy young adult participants to complete a laboratory-based social stressor while markers of inflammatory activity were obtained from oral fluids. A subset of participants (n = 31) later completed an fMRI session in which their neural responses to social rejection were assessed. As predicted, exposure to the laboratory-based social stressor was associated with significant increases in two markers of inflammatory activity, namely a soluble receptor for tumor necrosis factor-alpha (sTNFalphaRII) and interleukin-6 (IL-6). In the neuroimaging subsample, greater increases in sTNFalphaRII (but not IL-6) were associated with greater activity in the dorsal anterior cingulate cortex and anterior insula, brain regions that have previously been associated with processing rejection-related distress and negative affect. These data thus elucidate a neurocognitive pathway that may be involved in potentiated inflammatory responses to acute social stress. As such, they have implications for understanding how social stressors may promote susceptibility to diseases with an inflammatory component.

Indexed as

AdolescentAdultBrainDepressionEnzyme-Linked Immunosorbent AssayExudates and TransudatesFemaleHumansInflammationInterleukin-6Interpersonal RelationsMagnetic Resonance ImagingMaleMouth MucosaNeural PathwaysReceptors, Tumor Necrosis Factor, Type IIInterleukin-6Receptors, Tumor Necrosis Factor, Type IITumor Necrosis Factor-alpha

Identifiers

PMID20679216
PMCPMC2930449
OpenAlexW2119650117

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.