ArticleProceedings of the National Academy of Sciences of the United States of America2010
A subtilisin-like protein from soybean contains an embedded, cryptic signal that activates defense-related genes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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Who cites it
63 citing papers in PubMed, 118 citations in OpenAlex.
- Diverse phytocytokines derived from conserved subtilase scaffolds co-evolved with clustered receptors to confer defence responses in legumes.Nature plants · 2026Article
- Epigenetic regulation of TaFIP phytocytokine clusters confers basal resistance via receptor kinase TaFIPR in wheat.Nature plants · 2026Article
- Processing and release of endogenous immunogenic peptide signals.The Plant journal : for cell and molecular biology · 2026Review
- PROSiCAPE14 regulates salt tolerance through ROS and ion homeostasis in foxtail millet.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Plant non-canonical peptides: From identification to mechanisms.Plant communications · 2026Review
- Simple molecules make difference: short peptides play a novel role in slowing senescence.npj aging · 2025Review
- Long-Term Phytaspase Responses inInternational journal of molecular sciences · 2025Article
- Peptide hormones in plants.Molecular horticulture · 2025Review
- Modeling Chickpea Productivity with Artificial Image Objects and Convolutional Neural Network.Plants (Basel, Switzerland) · 2024Article
- Unraveling a Small Secreted Peptide SUBPEP3 That Positively Regulates Salt-Stress Tolerance inInternational journal of molecular sciences · 2024Article
- Subtilases: a major prospect to the genome editing in horticultural crops.Frontiers in plant science · 2024Review
- Molecular Mechanisms of Regulation of Root Development by Plant Peptides.Plants (Basel, Switzerland) · 2023Review
- Small Signals Lead to Big Changes: The Potential of Peptide-Induced Resistance in Plants.Journal of fungi (Basel, Switzerland) · 2023Review
- Elicitation of Roots and AC-DC with PEP-13 Peptide Shows Differential Defense Responses in Multi-Omics.Cells · 2022Article
- Progress in soybean functional genomics over the past decade.Plant biotechnology journal · 2022Review
- Plant immunity inducers: from discovery to agricultural application.Stress biology · 2022Review
- Article
- Metabolomics by UHPLC-HRMS reveals the impact of heat stress on pathogen-elicited immunity in maize.Metabolomics : Official journal of the Metabolomic Society · 2021Article
- Secretory Peptides as Bullets: Effector Peptides from Pathogens against Antimicrobial Peptides from Soybean.International journal of molecular sciences · 2020Review
- The RsRlpA Effector Is a Protease Inhibitor PromotingInternational journal of molecular sciences · 2020Article
3 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Among the arsenal of plant-derived compounds activated upon attack by herbivores and pathogens are small peptides that initiate and amplify defense responses. However, only a handful of plant signaling peptides have been reported. Here, we have isolated a 12-aa peptide from soybean (Glycine max) leaves that causes a pH increase of soybean suspension-cultured cell media within 10 min at low nanomolar concentrations, a response that is typical of other endogenous peptide elicitors and pathogen-derived elicitors. The amino acid sequence was determined and was found to be derived from a member of the subtilisin-like protease (subtilase) family. The sequence of the peptide was located within a region of the protein that is unique to subtilases in legume plants and not found within any other plant subtilases thus far identified. We have named this peptide signal Glycine max Subtilase Peptide (GmSubPep). The gene (Glyma18g48580) was expressed in all actively growing tissues of the soybean plant. Although transcription of Glyma18g48580 was not induced by wounding, methyl jasmonate, methyl salicylate, or ethephon, synthetic GmSubPep peptide, when supplied to soybean cultures, induced the expression of known defense-related genes, such as Cyp93A1, Chib-1b, PDR12, and achs. GmSubPep is a unique plant defense peptide signal, cryptically embedded within a plant protein with an independent metabolic role, providing insights into plant defense mechanisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.