ArticleArchives of pediatrics & adolescent medicine2010
Effects of unilateral clefts on brain structure.
Article in Archives of pediatrics & adolescent medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- A Review and Meta-Analysis on Altered Brain Structure in Patients Born with Non-Syndromic Cleft Lip and/or Palate.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2026Pooled it
- The Brain in Oral Clefting: A Systematic Review With Meta-Analyses.Frontiers in neuroanatomy · 2022Pooled it
- Cleft Laterality Dental Arch Relationship Outcomes for Children with Unilateral Cleft Lip and Palate in New Zealand.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2025Article
- The Influence of Sidedness in Unilateral Cleft Lip and Palate on Mid Facial Growth at Five Years of Age.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2025Article
- Sidedness in Unilateral Orofacial Clefts: A Systematic Scoping Review.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2025Article
- Birth Defect Co-Occurrence Patterns Among Infants With Cleft Lip and/or Palate.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2022Article
- Common basis for orofacial clefting and cortical interneuronopathy.Translational psychiatry · 2018Article
- Laterality of Oral Clefts and Academic Achievement.Pediatrics · 2017Article
- Academic achievement in children with oral clefts versus unaffected siblings.Journal of pediatric psychology · 2014Article
- Haploinsufficiency of interferon regulatory factor 6 alters brain morphology in the mouse.American journal of medical genetics. Part A · 2014Article
- Social motivation in individuals with isolated cleft lip and palate.Journal of clinical and experimental neuropsychology · 2013Article
- Height, BMI, and pituitary volume in individuals with and without isolated cleft lip and/or palate.Pediatric research · 2012Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo evaluate potential abnormalities in brain structure of children and adolescents with unilateral clefts.
designCase-control study.
settingTertiary care center.
participantsBoys aged 7 to 17 years with right (n=14) and left (n=19) clefts were compared with healthy age-matched boys (n=57). MAIN EXPOSURES: Structural brain measures were obtained using magnetic resonance imaging. OUTCOME MEASURE: It was explored whether laterality of clefts had a significant effect on brain structure. To this end, volumes of tissue types and various brain regions were evaluated.
resultsTotal white matter was significantly lower in boys with right clefts compared with boys with left clefts and healthy boys. Gross regional analyses demonstrated that reductions in white matter were evident in both the cerebellum and the cerebrum in boys with right clefts. Furthermore, within the cerebrum, white matter volumes were particularly low in the frontal lobes and the occipital lobes.
conclusionsThese preliminary results suggest that right clefts may be associated with more abnormalities in brain structure. More generally, laterality of a birth defect may have a significant effect on a developing organism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.