ArticleArchives of pediatrics & adolescent medicine2010
Malnutrition and hemodynamic status in adolescents hospitalized for anorexia nervosa.
Article in Archives of pediatrics & adolescent medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.
- Momentary physiological indices related to eating disorders: A systematic and methodological review.European eating disorders review : the journal of the Eating Disorders Association · 2024Pooled it
- Refeeding hypophosphatemia in adolescents with anorexia nervosa: a systematic review.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2013Pooled it
- Echocardiographic findings of cardiac abnormalities in children and adolescents with anorexia nervosa: a systematic review.Journal of eating disorders · 2026Review
- QTc interval prolongation in pediatric eating disorder population.Frontiers in pediatrics · 2026Article
- Incidence and Risk of Cardiovascular Outcomes in Patients With Anorexia Nervosa.JAMA network open · 2024Article
- Severe Sinus Bradycardia in Anorexia Nervosa: A Case Report and Focused Review of Cardiovascular Complications.Cureus · 2024Article
- QTc Interval Prolongation and Its Association With Electrolyte Abnormalities and Psychotropic Drug Use Among Patients With Eating Disorders.CJC pediatric and congenital heart disease · 2024Article
- Medical instability in typical and atypical adolescent anorexia nervosa: a systematic review and meta-analysis.Journal of eating disorders · 2023Review
- Assessment and management of cardiovascular complications in eating disorders.Journal of eating disorders · 2023Review
- Cardiac Complications Associated with Eating Disorders in Children: A Multicenter Retrospective Study.Pediatric gastroenterology, hepatology & nutrition · 2022Article
- Echocardiographic changes in anorexia nervosa: a pathophysiological adaptation or a disease?Internal and emergency medicine · 2022Article
- Self-Reported Lifetime History of Eating Disorders and Mortality in the General Population: A Canadian Population Survey with Record Linkage.Nutrients · 2021Article
- Heart and anorexia nervosa.Heart failure reviews · 2021Review
- Role of Neuroendocrine, Immune, and Autonomic Nervous System in Anorexia Nervosa-Linked Cardiovascular Diseases.International journal of molecular sciences · 2020Review
- Severe food restriction activates the central renin angiotensin system.Physiological reports · 2020Article
- What is the evidence for using bed rest as part of hospital treatment of severe anorexia nervosa?Evidence-based mental health · 2019Review
- Chronotropic incompetence to exercise in anorexia nervosa patients during the body-weight recovery phase as an index of insufficient treatment.Heart and vessels · 2019Article
- Role of the Renin Angiotensin System in Blood Pressure Allostasis-induced by Severe Food Restriction in Female Fischer rats.Scientific reports · 2018Article
- Evaluation and management of bradycardia in neonates and children.European journal of pediatrics · 2016Review
- Relationship between duration of illness and cardiac autonomic nervous activity in anorexia nervosa.BioPsychoSocial medicine · 2015Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo determine the effects of malnutrition on hemodynamic status of adolescents hospitalized for anorexia nervosa.
designLongitudinal observational study.
settingTertiary care pediatric hospital. Patients Thirty-eight adolescents with anorexia nervosa, aged 13 to 21 years, with a mean (SD) body mass index (calculated as weight in kilograms divided by height in meters squared) of 15.9 (1.8). Intervention Subjects received standard care, including bed rest and graded nutritional therapy. A subsample of subjects (n=19) returned 11 to 57 weeks following hospitalization for a second cardiac evaluation.
main outcome measuresResults from a 15-lead electrocardiogram, echocardiogram, treadmill stress test, and spinal bone mineral density measurement.
resultsOn admission, 26 subjects (68%) had sinus bradycardia. Bradycardia was less common in participants with a longer duration of illness (P=.04). Left ventricle mass was lower than predicted for age (Z score<-1.0) in 11 subjects (31%). Exercise tolerance was normal by all measures. Both heart rate and QT interval were predictors of spinal bone mineral density. In those who returned for follow-up, absolute measures of left ventricle mass did not change (P=.27). However, the corresponding Z scores declined over time (mean [SD] change, -0.9 [1.3]; P=.02).
conclusionsIn acutely malnourished adolescents with anorexia nervosa, few truly pathologic cardiac findings were identified. Sinus bradycardia was observed in most cases. Mild reductions in left ventricle mass and left ventricle function were seen both at baseline and at follow-up, suggesting early sparing of cardiac muscle in the face of moderate malnutrition as well as a relative delay of cardiac muscle restoration. The association of hemodynamic status with altered spinal bone mineral density emphasizes the range of systems affected by malnutrition in anorexia nervosa.
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Registered trials
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